node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS61601.1 | ACS61602.1 | Rpic12D_0294 | Rpic12D_0295 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.992 |
ACS61601.1 | ACS61907.1 | Rpic12D_0294 | Rpic12D_0602 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.631 |
ACS61601.1 | kdsA | Rpic12D_0294 | Rpic12D_1066 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: rso:RSc1127 2-dehydro-3-deoxyphosphooctonate aldolase. | 0.986 |
ACS61601.1 | kdsB | Rpic12D_0294 | Rpic12D_2403 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.981 |
ACS61601.1 | lpxA | Rpic12D_0294 | Rpic12D_1354 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.739 |
ACS61601.1 | lpxB | Rpic12D_0294 | Rpic12D_1355 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.708 |
ACS61601.1 | lpxC | Rpic12D_0294 | Rpic12D_2717 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.740 |
ACS61601.1 | lpxD | Rpic12D_0294 | Rpic12D_1352 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.719 |
ACS61601.1 | lpxK | Rpic12D_0294 | Rpic12D_2401 | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.686 |
ACS61602.1 | ACS61601.1 | Rpic12D_0295 | Rpic12D_0294 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | 0.992 |
ACS61602.1 | ACS61907.1 | Rpic12D_0295 | Rpic12D_0602 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.885 |
ACS61602.1 | kdsA | Rpic12D_0295 | Rpic12D_1066 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: rso:RSc1127 2-dehydro-3-deoxyphosphooctonate aldolase. | 0.991 |
ACS61602.1 | kdsB | Rpic12D_0295 | Rpic12D_2403 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.905 |
ACS61602.1 | lpxA | Rpic12D_0295 | Rpic12D_1354 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.880 |
ACS61602.1 | lpxB | Rpic12D_0295 | Rpic12D_1355 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.863 |
ACS61602.1 | lpxC | Rpic12D_0295 | Rpic12D_2717 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.865 |
ACS61602.1 | lpxD | Rpic12D_0295 | Rpic12D_1352 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.901 |
ACS61602.1 | lpxK | Rpic12D_0295 | Rpic12D_2401 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.896 |
ACS61602.1 | pyrG | Rpic12D_0295 | Rpic12D_1065 | KpsF/GutQ family protein; KEGG: rso:RSc0413 hypothetical protein; TIGRFAM: KpsF/GutQ family protein; PFAM: sugar isomerase (SIS); CBS domain containing protein; SMART: CBS domain containing protein; Belongs to the SIS family. GutQ/KpsF subfamily. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.470 |
ACS61907.1 | ACS61601.1 | Rpic12D_0602 | Rpic12D_0294 | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | TIGRFAM: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family; hydrolase, HAD-superfamily, subfamily IIIA; KEGG: rso:RSc0412 hypothetical protein. | 0.631 |