node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS62773.1 | ACS62774.1 | Rpic12D_1486 | Rpic12D_1487 | KEGG: rso:RSc1761 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | 0.651 |
ACS62773.1 | ACS62775.1 | Rpic12D_1486 | Rpic12D_1488 | KEGG: rso:RSc1761 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: rso:RSc1759 trifunctonal enoyl-CoA hydratase/delta3-cis-delta2-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase. | 0.999 |
ACS62774.1 | ACS62773.1 | Rpic12D_1487 | Rpic12D_1486 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | KEGG: rso:RSc1761 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.651 |
ACS62774.1 | ACS62775.1 | Rpic12D_1487 | Rpic12D_1488 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: rso:RSc1759 trifunctonal enoyl-CoA hydratase/delta3-cis-delta2-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase. | 0.695 |
ACS62774.1 | ACS64837.1 | Rpic12D_1487 | Rpic12D_3577 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.990 |
ACS62774.1 | cobB | Rpic12D_1487 | Rpic12D_1166 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | PFAM: Silent information regulator protein Sir2; KEGG: rso:RSc1230 hypothetical protein; Belongs to the sirtuin family. Class III subfamily. | 0.916 |
ACS62774.1 | guaA | Rpic12D_1487 | Rpic12D_1372 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | 0.401 |
ACS62774.1 | nadE | Rpic12D_1487 | Rpic12D_2158 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.579 |
ACS62774.1 | nnrD | Rpic12D_1487 | Rpic12D_1527 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.463 |
ACS62774.1 | pncB | Rpic12D_1487 | Rpic12D_0961 | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.973 |
ACS62775.1 | ACS62773.1 | Rpic12D_1488 | Rpic12D_1486 | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: rso:RSc1759 trifunctonal enoyl-CoA hydratase/delta3-cis-delta2-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase. | KEGG: rso:RSc1761 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.999 |
ACS62775.1 | ACS62774.1 | Rpic12D_1488 | Rpic12D_1487 | PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: rso:RSc1759 trifunctonal enoyl-CoA hydratase/delta3-cis-delta2-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase. | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | 0.695 |
ACS64837.1 | ACS62774.1 | Rpic12D_3577 | Rpic12D_1487 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | 0.990 |
ACS64837.1 | nadE | Rpic12D_3577 | Rpic12D_2158 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.722 |
ACS64837.1 | pncB | Rpic12D_3577 | Rpic12D_0961 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.900 |
cobB | ACS62774.1 | Rpic12D_1166 | Rpic12D_1487 | PFAM: Silent information regulator protein Sir2; KEGG: rso:RSc1230 hypothetical protein; Belongs to the sirtuin family. Class III subfamily. | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | 0.916 |
cobB | nadE | Rpic12D_1166 | Rpic12D_2158 | PFAM: Silent information regulator protein Sir2; KEGG: rso:RSc1230 hypothetical protein; Belongs to the sirtuin family. Class III subfamily. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.960 |
cobB | nnrD | Rpic12D_1166 | Rpic12D_1527 | PFAM: Silent information regulator protein Sir2; KEGG: rso:RSc1230 hypothetical protein; Belongs to the sirtuin family. Class III subfamily. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.560 |
guaA | ACS62774.1 | Rpic12D_1372 | Rpic12D_1487 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Nicotinamidase; PFAM: isochorismatase hydrolase; KEGG: rso:RSc1760 bifunctional pyrazinamidase/nicotinamidase hydrolase. | 0.401 |
guaA | nadE | Rpic12D_1372 | Rpic12D_2158 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.657 |