STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Adeg_0010KEGG: sat:SYN_00123 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein. (527 aa)    
Predicted Functional Partners:
Adeg_0009
PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: dvu:DVU0494 aminotransferase, class V.
 
  
 0.931
Adeg_1862
PFAM: phosphoribulokinase/uridine kinase; KEGG: phosphoribulokinase; K00855 phosphoribulokinase.
   
  0.906
Adeg_0182
KEGG: geo:Geob_2765 proposed homoserine kinase; TIGRFAM: proposed homoserine kinase; phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein.
    
 0.901
Adeg_1600
Phosphonopyruvate decarboxylase-related protein; KEGG: sat:SYN_02641 cofactor-independent phosphoglycerate mutase; TIGRFAM: phosphonopyruvate decarboxylase-related protein; PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; metalloenzyme domain protein.
    
 0.901
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
  
 0.894
serS
seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).
  
  
 0.793
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.790
Adeg_0162
TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: dma:DMR_17120 cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.757
Adeg_0383
PFAM: glutamate synthase alpha subunit domain protein; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: sfu:Sfum_1723 FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
  
  
 0.738
Adeg_1102
PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: scl:sce6432 3-isopropylmalate dehydrogenase.
  
  
 0.738
Your Current Organism:
Ammonifex degensii
NCBI taxonomy Id: 429009
Other names: A. degensii KC4, Ammonifex degensii KC4, Ammonifex degensii str. KC4, Ammonifex degensii strain KC4
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