Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
disADNA integrity scanning, DisA, linker region; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis. (352 aa)    
Predicted Functional Partners:
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.935
Adeg_0393
DNA-(apurinic or apyrimidinic site) lyase; KEGG: lch:Lcho_2655 endonuclease III; PFAM: HhH-GPD family protein; iron-sulfur cluster loop; SMART: HhH-GPD family protein.
 
     0.723
Adeg_0394
PFAM: Appr-1-p processing domain protein; SMART: Appr-1-p processing domain protein; KEGG: tgr:Tgr7_0121 Appr-1-p processing domain protein.
       0.701
Adeg_0395
TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase family 51; penicillin-binding protein transpeptidase; KEGG: sat:SYN_00304 multimodular transpeptidase-transglycosylase.
       0.701
Adeg_0392
PFAM: protein of unknown function DUF81; KEGG: dvl:Dvul_2200 hypothetical protein.
       0.673
Adeg_1177
PFAM: Bifunctional DNA primase/polymerase; Primase 1; KEGG: dol:Dole_2704 bifunctional DNA primase/polymerase.
  
  
 0.634
Adeg_2001
PFAM: Bifunctional DNA primase/polymerase; Primase 1; KEGG: dol:Dole_2704 bifunctional DNA primase/polymerase.
  
  
 0.634
ispDF
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
  
    0.584
Adeg_0400
PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein PINc; KEGG: sat:SYN_01402 hypothetical protein.
  
  
 0.527
Adeg_0391
PFAM: Anthranilate synthase component I domain protein; Chorismate binding-like; KEGG: pla:Plav_1564 para-aminobenzoate synthase, subunit I.
     
 0.496
Your Current Organism:
Ammonifex degensii
NCBI taxonomy Id: 429009
Other names: A. degensii KC4, Ammonifex degensii KC4, Ammonifex degensii str. KC4, Ammonifex degensii strain KC4
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