A0A182JSP4 protein (Anopheles christyi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

A0A182JSP4

Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (765 aa)

Predicted Functional Partners:

A0A182JNG9

0.998

A0A182JNM1

0.998

A0A182JUQ1

0.995

A0A182K8Y8

0.989

A0A182JTF2

0.987

A0A182JNI4

0.979

A0A182K523

0.975

A0A182K6K1

0.952

A0A182KAY1

0.952

A0A182JSU4

0.950

Your Current Organism:

Anopheles christyi

NCBI taxonomy Id: 43041
Other names: A. christyi

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A182JNG9	A0A182JNI4	Uncharacterized protein.	USP8_dimer domain-containing protein.	0.990
A0A182JNG9	A0A182JNM1	Uncharacterized protein.	Uncharacterized protein.	0.993
A0A182JNG9	A0A182JSP4	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.998
A0A182JNG9	A0A182JSU4	Uncharacterized protein.	Uncharacterized protein.	0.807
A0A182JNG9	A0A182JTF2	Uncharacterized protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.955
A0A182JNG9	A0A182JUQ1	Uncharacterized protein.	Uncharacterized protein.	0.950
A0A182JNG9	A0A182K523	Uncharacterized protein.	Uncharacterized protein.	0.638
A0A182JNG9	A0A182K6K1	Uncharacterized protein.	VPS37 C-terminal domain-containing protein.	0.979
A0A182JNG9	A0A182K8Y8	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.990
A0A182JNG9	A0A182KAY1	Uncharacterized protein.	Uncharacterized protein.	0.960
A0A182JNI4	A0A182JNG9	USP8_dimer domain-containing protein.	Uncharacterized protein.	0.990
A0A182JNI4	A0A182JSP4	USP8_dimer domain-containing protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.979
A0A182JNI4	A0A182K523	USP8_dimer domain-containing protein.	Uncharacterized protein.	0.648
A0A182JNI4	A0A182KAY1	USP8_dimer domain-containing protein.	Uncharacterized protein.	0.756
A0A182JNM1	A0A182JNG9	Uncharacterized protein.	Uncharacterized protein.	0.993
A0A182JNM1	A0A182JSP4	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.998
A0A182JNM1	A0A182K523	Uncharacterized protein.	Uncharacterized protein.	0.935
A0A182JNM1	A0A182K6K1	Uncharacterized protein.	VPS37 C-terminal domain-containing protein.	0.997
A0A182JNM1	A0A182K8Y8	Uncharacterized protein.	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.	0.999
A0A182JNM1	A0A182KAY1	Uncharacterized protein.	Uncharacterized protein.	0.916

page 1 of 4

Server load: medium (46%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About