Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
A0A182K008DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1178 aa)    
Predicted Functional Partners:
A0A182JP70
DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
0.999
A0A182K9U6
DNA_mis_repair domain-containing protein.
 
 0.999
A0A182JND7
Uncharacterized protein.
  
 0.998
A0A182JPH1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.997
A0A182K160
Uncharacterized protein.
   
 0.988
Fen1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.984
A0A182JZP9
DNA polymerase.
   
 
 0.981
A0A182JXH0
DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.
   
 
 0.974
A0A182JRW5
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.973
A0A182KEY8
DDE_Tnp_IS1595 domain-containing protein.
  
 0.969
Your Current Organism:
Anopheles christyi
NCBI taxonomy Id: 43041
Other names: A. christyi
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