STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FLM9_1247Threonine synthase (EC 4.2.3.1); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (374 aa)    
Predicted Functional Partners:
thrB
Homoserine kinase (EC 2.7.1.39); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.968
ilvA
Threonine dehydratase biosynthetic (EC 4.3.1.19); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
0.902
FLM9_1169
Threonine synthase (EC 4.2.3.1); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
  
  
 
0.883
FLM9_867
Sulfur acceptor protein SufE for iron-sulfur cluster assembly.
 
      0.631
ilvC
Ketol-acid reductoisomerase (EC 1.1.1.86); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.620
FLM9_83
Aspartokinase (EC 2.7.2.4).
  
 
 0.619
FLM9_1246
Hypothetical protein.
       0.610
ilvE
Branched-chain amino acid aminotransferase (EC 2.6.1.42); Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 0.599
FLM9_1042
Ferredoxin-dependent glutamate synthase (EC 1.4.7.1).
  
  
 0.579
FLM9_278
Glutamate synthase [NADPH] large chain (EC 1.4.1.13).
  
  
 0.579
Your Current Organism:
Synechococcus spongiarum
NCBI taxonomy Id: 431041
Other names: C. Synechococcus spongiarum, Candidatus Synechococcus spongiarum
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