Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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glnDPII-uridylyltransferase/Glutamine-synthetase adenylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (982 aa)    
Predicted Functional Partners:
glnB
Nitrogen regulatory protein PII; Belongs to the P(II) protein family.
 
 
 0.968
glnK
Nitrogen regulatory protein PII; Belongs to the P(II) protein family.
 
 
 0.808
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.785
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA.
       0.701
ntrB
Two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL; [EC:2.7.13.3]; two component sensor histidine kinase NtrB.
  
 
 
 0.607
gltS
[EC:1.4.7.1]; glutamate synthase (NADPH) large subunit (EC:1.4.1.13).
     
 0.605
AGA_2077
TPR repeat-containing protein; Tetratricopeptide TPR2.
       0.516
papS
poly(A) polymerase; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
     
  0.507
amtB
Ammonium transporter.
     
 0.491
yaeT
Outer membrane protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.485
Your Current Organism:
Acetobacter ghanensis
NCBI taxonomy Id: 431306
Other names: A. ghanensis, Acetobacter ghanensis Cleenwerck et al. 2007, Acetobacter sp. 384, Acetobacter sp. 444B, DSM 18895, LMG 23848, LMG:23848, strain 430A, strain R-29337
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