| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGA_504 | RutE | AGA_504 | AGA_503 | Peptidase M22, glycoprotease. | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | 0.834 |
| AGA_504 | nifU-2 | AGA_504 | AGA_502 | Peptidase M22, glycoprotease. | Scaffold protein Nfu/NifU; NIF system FeS cluster assembly, NifU-like scaffold, N-terminal. | 0.648 |
| AGA_504 | rimI | AGA_504 | AGA_505 | Peptidase M22, glycoprotease. | Ribosomal-protein-alanine N-acetyltransferase. | 0.886 |
| AGA_757 | RutE | AGA_757 | AGA_503 | Hypothetical protein. | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | 0.406 |
| RutE | AGA_504 | AGA_503 | AGA_504 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | Peptidase M22, glycoprotease. | 0.834 |
| RutE | AGA_757 | AGA_503 | AGA_757 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | Hypothetical protein. | 0.406 |
| RutE | cysG | AGA_503 | AGA_1919 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.814 |
| RutE | gltS | AGA_503 | AGA_2346 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | [EC:1.4.7.1]; glutamate synthase (NADPH) large subunit (EC:1.4.1.13). | 0.442 |
| RutE | metH | AGA_503 | AGA_206 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.425 |
| RutE | nifU-2 | AGA_503 | AGA_502 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | Scaffold protein Nfu/NifU; NIF system FeS cluster assembly, NifU-like scaffold, N-terminal. | 0.649 |
| RutE | rimI | AGA_503 | AGA_505 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | Ribosomal-protein-alanine N-acetyltransferase. | 0.832 |
| RutE | rutF | AGA_503 | AGA_986 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | Putative flavin reductase RutF. | 0.666 |
| RutE | ssuD | AGA_503 | AGA_1857 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | Alkanesulfonate monooxygenase. | 0.425 |
| RutE | ydfG | AGA_503 | AGA_1090 | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.880 |
| cysG | RutE | AGA_1919 | AGA_503 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | 0.814 |
| cysG | gltS | AGA_1919 | AGA_2346 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | [EC:1.4.7.1]; glutamate synthase (NADPH) large subunit (EC:1.4.1.13). | 0.553 |
| cysG | metH | AGA_1919 | AGA_206 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.639 |
| gltS | RutE | AGA_2346 | AGA_503 | [EC:1.4.7.1]; glutamate synthase (NADPH) large subunit (EC:1.4.1.13). | [EC:1.-.-.-]; NADH dehydrogenase, Nitroreductase-like. | 0.442 |
| gltS | cysG | AGA_2346 | AGA_1919 | [EC:1.4.7.1]; glutamate synthase (NADPH) large subunit (EC:1.4.1.13). | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.553 |
| gltS | metH | AGA_2346 | AGA_206 | [EC:1.4.7.1]; glutamate synthase (NADPH) large subunit (EC:1.4.1.13). | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.517 |