INSR protein (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

INSR

Tyrosine-protein kinase receptor. (1359 aa)

Predicted Functional Partners:

Ins

0.995

IGF1

0.995

IGF1R

0.991

LOC101974931

0.989

GRB10

0.987

PTPN1

0.986

PIK3R1

0.985

GRB14

0.980

IRS1

0.976

IGF2

0.972

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GRB10	IGF1	ENSSTOP00000024400	ENSSTOP00000029785	Growth factor receptor bound protein 10.	Insulin like growth factor 1.	0.605
GRB10	IGF1R	ENSSTOP00000024400	ENSSTOP00000010241	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.992
GRB10	IGF2	ENSSTOP00000024400	ENSSTOP00000018700	Growth factor receptor bound protein 10.	Insulin like growth factor 2.	0.601
GRB10	INSR	ENSSTOP00000024400	ENSSTOP00000000977	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.987
GRB10	IRS1	ENSSTOP00000024400	ENSSTOP00000017790	Growth factor receptor bound protein 10.	Insulin receptor substrate 1.	0.634
GRB10	Ins	ENSSTOP00000024400	ENSSTOP00000017025	Growth factor receptor bound protein 10.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.723
GRB10	LOC101974931	ENSSTOP00000024400	ENSSTOP00000018815	Growth factor receptor bound protein 10.	Tyrosine-protein phosphatase non-receptor type.	0.484
GRB10	PIK3R1	ENSSTOP00000024400	ENSSTOP00000026032	Growth factor receptor bound protein 10.	Phosphoinositide-3-kinase regulatory subunit 1.	0.842
GRB10	PTPN1	ENSSTOP00000024400	ENSSTOP00000020149	Growth factor receptor bound protein 10.	Tyrosine-protein phosphatase non-receptor type.	0.476
GRB14	IGF1R	ENSSTOP00000014065	ENSSTOP00000010241	Growth factor receptor bound protein 14.	Tyrosine-protein kinase receptor.	0.854
GRB14	INSR	ENSSTOP00000014065	ENSSTOP00000000977	Growth factor receptor bound protein 14.	Tyrosine-protein kinase receptor.	0.980
GRB14	IRS1	ENSSTOP00000014065	ENSSTOP00000017790	Growth factor receptor bound protein 14.	Insulin receptor substrate 1.	0.518
GRB14	Ins	ENSSTOP00000014065	ENSSTOP00000017025	Growth factor receptor bound protein 14.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.603
GRB14	LOC101974931	ENSSTOP00000014065	ENSSTOP00000018815	Growth factor receptor bound protein 14.	Tyrosine-protein phosphatase non-receptor type.	0.498
GRB14	PIK3R1	ENSSTOP00000014065	ENSSTOP00000026032	Growth factor receptor bound protein 14.	Phosphoinositide-3-kinase regulatory subunit 1.	0.685
GRB14	PTPN1	ENSSTOP00000014065	ENSSTOP00000020149	Growth factor receptor bound protein 14.	Tyrosine-protein phosphatase non-receptor type.	0.483
IGF1	GRB10	ENSSTOP00000029785	ENSSTOP00000024400	Insulin like growth factor 1.	Growth factor receptor bound protein 10.	0.605
IGF1	IGF1R	ENSSTOP00000029785	ENSSTOP00000010241	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.997
IGF1	IGF2	ENSSTOP00000029785	ENSSTOP00000018700	Insulin like growth factor 1.	Insulin like growth factor 2.	0.934
IGF1	INSR	ENSSTOP00000029785	ENSSTOP00000000977	Insulin like growth factor 1.	Tyrosine-protein kinase receptor.	0.995