| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CACNA1C | PRKACA | ENSSTOP00000013255 | ENSSTOP00000002080 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. | 0.989 |
| CACNA1C | RYR2 | ENSSTOP00000013255 | ENSSTOP00000013195 | Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. | Ryanodine receptor 2. | 0.986 |
| CREB1 | I3MMQ2_ICTTR | ENSSTOP00000014755 | ENSSTOP00000012833 | cAMP responsive element binding protein 1. | Uncharacterized protein. | 0.420 |
| CREB1 | PRKACA | ENSSTOP00000014755 | ENSSTOP00000002080 | cAMP responsive element binding protein 1. | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. | 0.988 |
| CREB1 | PRKAR1A | ENSSTOP00000014755 | ENSSTOP00000011561 | cAMP responsive element binding protein 1. | Protein kinase cAMP-dependent type I regulatory subunit alpha. | 0.420 |
| CREB1 | PRKAR1B | ENSSTOP00000014755 | ENSSTOP00000003458 | cAMP responsive element binding protein 1. | Protein kinase cAMP-dependent type I regulatory subunit beta. | 0.416 |
| CREB1 | PRKAR2A | ENSSTOP00000014755 | ENSSTOP00000025533 | cAMP responsive element binding protein 1. | Protein kinase cAMP-dependent type II regulatory subunit alpha. | 0.416 |
| CREB1 | PRKAR2B | ENSSTOP00000014755 | ENSSTOP00000032214 | cAMP responsive element binding protein 1. | Protein kinase cAMP-dependent type II regulatory subunit beta. | 0.444 |
| I3MMQ2_ICTTR | CREB1 | ENSSTOP00000012833 | ENSSTOP00000014755 | Uncharacterized protein. | cAMP responsive element binding protein 1. | 0.420 |
| I3MMQ2_ICTTR | PLN | ENSSTOP00000012833 | ENSSTOP00000025174 | Uncharacterized protein. | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. | 0.418 |
| I3MMQ2_ICTTR | PRKACA | ENSSTOP00000012833 | ENSSTOP00000002080 | Uncharacterized protein. | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. | 0.995 |
| I3MMQ2_ICTTR | PRKAR1A | ENSSTOP00000012833 | ENSSTOP00000011561 | Uncharacterized protein. | Protein kinase cAMP-dependent type I regulatory subunit alpha. | 0.544 |
| I3MMQ2_ICTTR | PRKAR1B | ENSSTOP00000012833 | ENSSTOP00000003458 | Uncharacterized protein. | Protein kinase cAMP-dependent type I regulatory subunit beta. | 0.962 |
| I3MMQ2_ICTTR | PRKAR2A | ENSSTOP00000012833 | ENSSTOP00000025533 | Uncharacterized protein. | Protein kinase cAMP-dependent type II regulatory subunit alpha. | 0.972 |
| I3MMQ2_ICTTR | PRKAR2B | ENSSTOP00000012833 | ENSSTOP00000032214 | Uncharacterized protein. | Protein kinase cAMP-dependent type II regulatory subunit beta. | 0.990 |
| PKIA | PRKACA | ENSSTOP00000009610 | ENSSTOP00000002080 | cAMP-dependent protein kinase inhibitor; Belongs to the PKI family. | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. | 0.999 |
| PLN | I3MMQ2_ICTTR | ENSSTOP00000025174 | ENSSTOP00000012833 | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. | Uncharacterized protein. | 0.418 |
| PLN | PRKACA | ENSSTOP00000025174 | ENSSTOP00000002080 | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. | Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. | 0.985 |
| PLN | PRKAR1A | ENSSTOP00000025174 | ENSSTOP00000011561 | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. | Protein kinase cAMP-dependent type I regulatory subunit alpha. | 0.418 |
| PLN | PRKAR1B | ENSSTOP00000025174 | ENSSTOP00000003458 | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. | Protein kinase cAMP-dependent type I regulatory subunit beta. | 0.418 |
