| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATM | ENSSTOP00000024463 | ENSSTOP00000004029 | ENSSTOP00000024463 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | RING-type domain-containing protein. | 0.963 |
| ATM | I3MUQ5_ICTTR | ENSSTOP00000004029 | ENSSTOP00000015850 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | RING-type domain-containing protein. | 0.963 |
| ATM | Mdm2 | ENSSTOP00000004029 | ENSSTOP00000013171 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. | 0.997 |
| ATM | Mdm4 | ENSSTOP00000004029 | ENSSTOP00000003760 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.990 |
| ATM | TP53 | ENSSTOP00000004029 | ENSSTOP00000019678 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.999 |
| ATM | TP73 | ENSSTOP00000004029 | ENSSTOP00000022492 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.936 |
| ATM | USP7 | ENSSTOP00000004029 | ENSSTOP00000030771 | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.539 |
| ENSSTOP00000024463 | ATM | ENSSTOP00000024463 | ENSSTOP00000004029 | RING-type domain-containing protein. | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.963 |
| ENSSTOP00000024463 | Mdm4 | ENSSTOP00000024463 | ENSSTOP00000003760 | RING-type domain-containing protein. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.985 |
| ENSSTOP00000024463 | RB1 | ENSSTOP00000024463 | ENSSTOP00000000834 | RING-type domain-containing protein. | RB transcriptional corepressor 1. | 0.981 |
| ENSSTOP00000024463 | TP53 | ENSSTOP00000024463 | ENSSTOP00000019678 | RING-type domain-containing protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.991 |
| ENSSTOP00000024463 | TP73 | ENSSTOP00000024463 | ENSSTOP00000022492 | RING-type domain-containing protein. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.962 |
| ENSSTOP00000024463 | USP7 | ENSSTOP00000024463 | ENSSTOP00000030771 | RING-type domain-containing protein. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.955 |
| ENSSTOP00000024463 | YWHAB | ENSSTOP00000024463 | ENSSTOP00000003336 | RING-type domain-containing protein. | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. | 0.420 |
| I3MUQ5_ICTTR | ATM | ENSSTOP00000015850 | ENSSTOP00000004029 | RING-type domain-containing protein. | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. | 0.963 |
| I3MUQ5_ICTTR | Mdm4 | ENSSTOP00000015850 | ENSSTOP00000003760 | RING-type domain-containing protein. | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.985 |
| I3MUQ5_ICTTR | RB1 | ENSSTOP00000015850 | ENSSTOP00000000834 | RING-type domain-containing protein. | RB transcriptional corepressor 1. | 0.981 |
| I3MUQ5_ICTTR | TP53 | ENSSTOP00000015850 | ENSSTOP00000019678 | RING-type domain-containing protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.991 |
| I3MUQ5_ICTTR | TP73 | ENSSTOP00000015850 | ENSSTOP00000022492 | RING-type domain-containing protein. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.962 |
| I3MUQ5_ICTTR | USP7 | ENSSTOP00000015850 | ENSSTOP00000030771 | RING-type domain-containing protein. | Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. | 0.955 |
