STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTCH2Patched 2. (1197 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.989
SHH
Sonic hedgehog signaling molecule.
   
 0.986
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.985
IHH
Indian hedgehog signaling molecule.
   
 0.985
CDON
Cell adhesion associated, oncogene regulated.
    
 0.965
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.918
SMURF1
E3 ubiquitin-protein ligase.
    
 0.909
SMURF2
E3 ubiquitin-protein ligase.
    
 0.909
PTCH1
Patched 1.
  
  
0.859
GLI1
GLI family zinc finger 1.
   
 0.793
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.