Hspa5 protein (Ictidomys tridecemlineatus) - STRING interaction network

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Hspa5

Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (654 aa)

Predicted Functional Partners:

HSP90B1

0.998

HYOU1

0.998

MANF

0.996

ERN1

0.994

DNAJC10

0.994

PDIA3

0.989

Ern2

0.989

Dnajb11

0.986

EIF2AK3

0.986

P4HB

0.986

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNAJC10	Dnajb11	ENSSTOP00000023529	ENSSTOP00000008476	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	J domain-containing protein.	0.846
DNAJC10	ERN1	ENSSTOP00000023529	ENSSTOP00000008139	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Endoplasmic reticulum to nucleus signaling 1.	0.470
DNAJC10	Ern2	ENSSTOP00000023529	ENSSTOP00000011128	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Endoplasmic reticulum to nucleus signaling 2.	0.470
DNAJC10	HSP90B1	ENSSTOP00000023529	ENSSTOP00000004763	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Heat shock protein 90 beta family member 1.	0.984
DNAJC10	HYOU1	ENSSTOP00000023529	ENSSTOP00000012867	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Hypoxia up-regulated 1.	0.953
DNAJC10	Hspa5	ENSSTOP00000023529	ENSSTOP00000010092	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.994
DNAJC10	P4HB	ENSSTOP00000023529	ENSSTOP00000021866	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Protein disulfide-isomerase.	0.809
DNAJC10	PDIA3	ENSSTOP00000023529	ENSSTOP00000006163	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	Protein disulfide-isomerase.	0.715
Dnajb11	DNAJC10	ENSSTOP00000008476	ENSSTOP00000023529	J domain-containing protein.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.846
Dnajb11	HSP90B1	ENSSTOP00000008476	ENSSTOP00000004763	J domain-containing protein.	Heat shock protein 90 beta family member 1.	0.953
Dnajb11	HYOU1	ENSSTOP00000008476	ENSSTOP00000012867	J domain-containing protein.	Hypoxia up-regulated 1.	0.805
Dnajb11	Hspa5	ENSSTOP00000008476	ENSSTOP00000010092	J domain-containing protein.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.986
Dnajb11	MANF	ENSSTOP00000008476	ENSSTOP00000023565	J domain-containing protein.	Mesencephalic astrocyte derived neurotrophic factor.	0.847
Dnajb11	P4HB	ENSSTOP00000008476	ENSSTOP00000021866	J domain-containing protein.	Protein disulfide-isomerase.	0.491
Dnajb11	PDIA3	ENSSTOP00000008476	ENSSTOP00000006163	J domain-containing protein.	Protein disulfide-isomerase.	0.559
EIF2AK3	HSP90B1	ENSSTOP00000008691	ENSSTOP00000004763	Eukaryotic translation initiation factor 2 alpha kinase 3.	Heat shock protein 90 beta family member 1.	0.657
EIF2AK3	HYOU1	ENSSTOP00000008691	ENSSTOP00000012867	Eukaryotic translation initiation factor 2 alpha kinase 3.	Hypoxia up-regulated 1.	0.563
EIF2AK3	Hspa5	ENSSTOP00000008691	ENSSTOP00000010092	Eukaryotic translation initiation factor 2 alpha kinase 3.	Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...]	0.986
ERN1	DNAJC10	ENSSTOP00000008139	ENSSTOP00000023529	Endoplasmic reticulum to nucleus signaling 1.	DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.	0.470
ERN1	HSP90B1	ENSSTOP00000008139	ENSSTOP00000004763	Endoplasmic reticulum to nucleus signaling 1.	Heat shock protein 90 beta family member 1.	0.590

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