STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SOAT1O-acyltransferase. (544 aa)    
Predicted Functional Partners:
CH25H
Cholesterol 25-hydroxylase; Belongs to the sterol desaturase family.
   
 0.873
ENSSTOP00000026005
Uncharacterized protein.
    
 0.868
CYP46A1
Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family.
    
 0.858
DHCR24
24-dehydrocholesterol reductase.
     
 0.855
CYP7A1
Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.
     
 0.851
STS
Steroid sulfatase.
   
 
  0.850
CYP11A1
Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]
     
 0.848
CYP27A1
Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family.
     
 0.846
SOAT2
O-acyltransferase.
  
  
 
0.844
MSMO1
Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.
   
 0.843
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.