STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)    
Predicted Functional Partners:
DCAF7
DDB1 and CUL4 associated factor 7.
   
 
 0.971
FAM53C
Family with sequence similarity 53 member C.
    
 
 0.893
FAM117B
Family with sequence similarity 117 member B.
    
 
 0.838
RNF169
Ring finger protein 169.
    
 
 0.830
RAD54L2
RAD54 like 2.
    
 
 0.821
WDR26
WD repeat domain 26.
   
   0.803
LIN52
Lin-52 DREAM MuvB core complex component.
    
 0.784
ENSSTOP00000026561
Uncharacterized protein.
    
 0.758
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.750
C10orf71
Chromosome 10 open reading frame 71.
    
 
 0.714
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.