node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MED1 | NCOA1 | ENSSTOP00000017669 | ENSSTOP00000031631 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.886 |
MED1 | NCOA2 | ENSSTOP00000017669 | ENSSTOP00000021326 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.808 |
MED1 | NR1H2 | ENSSTOP00000017669 | ENSSTOP00000028032 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 1 group H member 2. | 0.844 |
MED1 | NR1H3 | ENSSTOP00000017669 | ENSSTOP00000027881 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor subfamily 1 group H member 3. | 0.844 |
MED1 | PPARA | ENSSTOP00000017669 | ENSSTOP00000009829 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator activated receptor alpha. | 0.963 |
MED1 | PPARG | ENSSTOP00000017669 | ENSSTOP00000011453 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.990 |
MED1 | RARA | ENSSTOP00000017669 | ENSSTOP00000025927 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor alpha. | 0.907 |
MED1 | RARB | ENSSTOP00000017669 | ENSSTOP00000007150 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor beta. | 0.959 |
MED1 | RXRA | ENSSTOP00000017669 | ENSSTOP00000016521 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor alpha. | 0.991 |
MED1 | THRB | ENSSTOP00000017669 | ENSSTOP00000004661 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Thyroid hormone receptor beta. | 0.937 |
NCOA1 | MED1 | ENSSTOP00000031631 | ENSSTOP00000017669 | Nuclear receptor coactivator. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.886 |
NCOA1 | NCOA2 | ENSSTOP00000031631 | ENSSTOP00000021326 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.976 |
NCOA1 | NR1H2 | ENSSTOP00000031631 | ENSSTOP00000028032 | Nuclear receptor coactivator. | Nuclear receptor subfamily 1 group H member 2. | 0.963 |
NCOA1 | NR1H3 | ENSSTOP00000031631 | ENSSTOP00000027881 | Nuclear receptor coactivator. | Nuclear receptor subfamily 1 group H member 3. | 0.970 |
NCOA1 | PPARA | ENSSTOP00000031631 | ENSSTOP00000009829 | Nuclear receptor coactivator. | Peroxisome proliferator activated receptor alpha. | 0.981 |
NCOA1 | PPARG | ENSSTOP00000031631 | ENSSTOP00000011453 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.985 |
NCOA1 | RARA | ENSSTOP00000031631 | ENSSTOP00000025927 | Nuclear receptor coactivator. | Retinoic acid receptor alpha. | 0.959 |
NCOA1 | RARB | ENSSTOP00000031631 | ENSSTOP00000007150 | Nuclear receptor coactivator. | Retinoic acid receptor beta. | 0.954 |
NCOA1 | RXRA | ENSSTOP00000031631 | ENSSTOP00000016521 | Nuclear receptor coactivator. | Retinoid X receptor alpha. | 0.994 |
NCOA1 | THRB | ENSSTOP00000031631 | ENSSTOP00000004661 | Nuclear receptor coactivator. | Thyroid hormone receptor beta. | 0.978 |