RUNX1 protein (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBFB	CDK6	ENSSTOP00000025127	ENSSTOP00000012566	Core-binding factor subunit beta.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.906
CBFB	EP300	ENSSTOP00000025127	ENSSTOP00000000650	Core-binding factor subunit beta.	E1A binding protein p300.	0.608
CBFB	FOXP3	ENSSTOP00000025127	ENSSTOP00000003963	Core-binding factor subunit beta.	Forkhead box P3.	0.830
CBFB	HDAC2	ENSSTOP00000025127	ENSSTOP00000011457	Core-binding factor subunit beta.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.470
CBFB	HDAC3	ENSSTOP00000025127	ENSSTOP00000014542	Core-binding factor subunit beta.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.469
CBFB	Hdac1	ENSSTOP00000025127	ENSSTOP00000010833	Core-binding factor subunit beta.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.477
CBFB	RUNX1	ENSSTOP00000025127	ENSSTOP00000017745	Core-binding factor subunit beta.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.984
CBFB	RUNX1T1	ENSSTOP00000025127	ENSSTOP00000028651	Core-binding factor subunit beta.	RUNX1 partner transcriptional co-repressor 1.	0.680
CDK6	CBFB	ENSSTOP00000012566	ENSSTOP00000025127	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Core-binding factor subunit beta.	0.906
CDK6	EP300	ENSSTOP00000012566	ENSSTOP00000000650	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	E1A binding protein p300.	0.636
CDK6	RUNX1	ENSSTOP00000012566	ENSSTOP00000017745	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.907
EP300	CBFB	ENSSTOP00000000650	ENSSTOP00000025127	E1A binding protein p300.	Core-binding factor subunit beta.	0.608
EP300	CDK6	ENSSTOP00000000650	ENSSTOP00000012566	E1A binding protein p300.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.636
EP300	FOS	ENSSTOP00000000650	ENSSTOP00000002680	E1A binding protein p300.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.986
EP300	FOXP3	ENSSTOP00000000650	ENSSTOP00000003963	E1A binding protein p300.	Forkhead box P3.	0.845
EP300	HDAC2	ENSSTOP00000000650	ENSSTOP00000011457	E1A binding protein p300.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.947
EP300	HDAC3	ENSSTOP00000000650	ENSSTOP00000014542	E1A binding protein p300.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.979
EP300	Hdac1	ENSSTOP00000000650	ENSSTOP00000010833	E1A binding protein p300.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.980
EP300	RUNX1	ENSSTOP00000000650	ENSSTOP00000017745	E1A binding protein p300.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.921
FOS	EP300	ENSSTOP00000002680	ENSSTOP00000000650	Fos proto-oncogene, AP-1 transcription factor subunit.	E1A binding protein p300.	0.986