node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACD | GAR1 | ENSSTOP00000014729 | ENSSTOP00000004985 | ACD shelterin complex subunit and telomerase recruitment factor. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.782 |
ACD | NHP2 | ENSSTOP00000014729 | ENSSTOP00000002881 | ACD shelterin complex subunit and telomerase recruitment factor. | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | 0.789 |
ACD | POT1 | ENSSTOP00000014729 | ENSSTOP00000030164 | ACD shelterin complex subunit and telomerase recruitment factor. | Protection of telomeres 1. | 0.997 |
ACD | RPA1 | ENSSTOP00000014729 | ENSSTOP00000016703 | ACD shelterin complex subunit and telomerase recruitment factor. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.647 |
ACD | TEP1 | ENSSTOP00000014729 | ENSSTOP00000009023 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase associated protein 1. | 0.421 |
ACD | TERT | ENSSTOP00000014729 | ENSSTOP00000019046 | ACD shelterin complex subunit and telomerase recruitment factor. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.980 |
ACD | WRAP53 | ENSSTOP00000014729 | ENSSTOP00000002217 | ACD shelterin complex subunit and telomerase recruitment factor. | WD repeat containing antisense to TP53. | 0.744 |
CTNNB1 | TERT | ENSSTOP00000014441 | ENSSTOP00000019046 | Catenin beta 1. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.943 |
GAR1 | ACD | ENSSTOP00000004985 | ENSSTOP00000014729 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.782 |
GAR1 | NHP2 | ENSSTOP00000004985 | ENSSTOP00000002881 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | 0.999 |
GAR1 | POT1 | ENSSTOP00000004985 | ENSSTOP00000030164 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | Protection of telomeres 1. | 0.856 |
GAR1 | TEP1 | ENSSTOP00000004985 | ENSSTOP00000009023 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | Telomerase associated protein 1. | 0.552 |
GAR1 | TERT | ENSSTOP00000004985 | ENSSTOP00000019046 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.963 |
GAR1 | WRAP53 | ENSSTOP00000004985 | ENSSTOP00000002217 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | WD repeat containing antisense to TP53. | 0.997 |
NHP2 | ACD | ENSSTOP00000002881 | ENSSTOP00000014729 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | ACD shelterin complex subunit and telomerase recruitment factor. | 0.789 |
NHP2 | GAR1 | ENSSTOP00000002881 | ENSSTOP00000004985 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. | 0.999 |
NHP2 | POT1 | ENSSTOP00000002881 | ENSSTOP00000030164 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | Protection of telomeres 1. | 0.804 |
NHP2 | TEP1 | ENSSTOP00000002881 | ENSSTOP00000009023 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | Telomerase associated protein 1. | 0.643 |
NHP2 | TERT | ENSSTOP00000002881 | ENSSTOP00000019046 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] | 0.965 |
NHP2 | WRAP53 | ENSSTOP00000002881 | ENSSTOP00000002217 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. | WD repeat containing antisense to TP53. | 0.996 |