node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DBT | DLAT | ENSSTOP00000012112 | ENSSTOP00000009985 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.737 |
DBT | DLD | ENSSTOP00000012112 | ENSSTOP00000006659 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | Dihydrolipoyl dehydrogenase. | 0.998 |
DBT | PDHA1 | ENSSTOP00000012112 | ENSSTOP00000013820 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.904 |
DBT | PDHB | ENSSTOP00000012112 | ENSSTOP00000019968 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.992 |
DBT | PDHX | ENSSTOP00000012112 | ENSSTOP00000003957 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.743 |
DBT | Pdk4 | ENSSTOP00000012112 | ENSSTOP00000019435 | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonge [...] | 0.783 |
DLAT | DBT | ENSSTOP00000009985 | ENSSTOP00000012112 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.737 |
DLAT | DLD | ENSSTOP00000009985 | ENSSTOP00000006659 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoyl dehydrogenase. | 0.999 |
DLAT | PDHA1 | ENSSTOP00000009985 | ENSSTOP00000013820 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
DLAT | PDHB | ENSSTOP00000009985 | ENSSTOP00000019968 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
DLAT | PDHX | ENSSTOP00000009985 | ENSSTOP00000003957 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.991 |
DLAT | Pdk4 | ENSSTOP00000009985 | ENSSTOP00000019435 | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonge [...] | 0.909 |
DLD | DBT | ENSSTOP00000006659 | ENSSTOP00000012112 | Dihydrolipoyl dehydrogenase. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.998 |
DLD | DLAT | ENSSTOP00000006659 | ENSSTOP00000009985 | Dihydrolipoyl dehydrogenase. | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
DLD | PDHA1 | ENSSTOP00000006659 | ENSSTOP00000013820 | Dihydrolipoyl dehydrogenase. | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.999 |
DLD | PDHB | ENSSTOP00000006659 | ENSSTOP00000019968 | Dihydrolipoyl dehydrogenase. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
DLD | PDHX | ENSSTOP00000006659 | ENSSTOP00000003957 | Dihydrolipoyl dehydrogenase. | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.999 |
DLD | Pdk4 | ENSSTOP00000006659 | ENSSTOP00000019435 | Dihydrolipoyl dehydrogenase. | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonge [...] | 0.787 |
MAP3K4 | Pdk4 | ENSSTOP00000002540 | ENSSTOP00000019435 | Mitogen-activated protein kinase kinase kinase 4. | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonge [...] | 0.893 |
PDHA1 | DBT | ENSSTOP00000013820 | ENSSTOP00000012112 | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. | 0.904 |