CSK protein (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CSK

Tyrosine-protein kinase. (450 aa)

Predicted Functional Partners:

PAG1

0.991

SRC

0.981

PTPN22

0.931

PTPN12

0.931

LYN

0.927

EGFR

0.900

HCK

0.877

LCK

0.876

FYN

0.834

PXN

0.827

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSK	EGFR	ENSSTOP00000020072	ENSSTOP00000006038	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.900
CSK	FYN	ENSSTOP00000020072	ENSSTOP00000006598	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.834
CSK	HCK	ENSSTOP00000020072	ENSSTOP00000004441	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.877
CSK	LCK	ENSSTOP00000020072	ENSSTOP00000010824	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.876
CSK	LYN	ENSSTOP00000020072	ENSSTOP00000029495	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.927
CSK	PAG1	ENSSTOP00000020072	ENSSTOP00000013929	Tyrosine-protein kinase.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.991
CSK	PTPN12	ENSSTOP00000020072	ENSSTOP00000020551	Tyrosine-protein kinase.	Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.	0.931
CSK	PTPN22	ENSSTOP00000020072	ENSSTOP00000013156	Tyrosine-protein kinase.	Protein tyrosine phosphatase non-receptor type 22.	0.931
CSK	PXN	ENSSTOP00000020072	ENSSTOP00000012629	Tyrosine-protein kinase.	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.	0.827
CSK	SRC	ENSSTOP00000020072	ENSSTOP00000014871	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.981
EGFR	CSK	ENSSTOP00000006038	ENSSTOP00000020072	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.900
EGFR	FYN	ENSSTOP00000006038	ENSSTOP00000006598	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.765
EGFR	HCK	ENSSTOP00000006038	ENSSTOP00000004441	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.673
EGFR	LCK	ENSSTOP00000006038	ENSSTOP00000010824	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.673
EGFR	LYN	ENSSTOP00000006038	ENSSTOP00000029495	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.876
EGFR	PAG1	ENSSTOP00000006038	ENSSTOP00000013929	Receptor protein-tyrosine kinase.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.632
EGFR	PTPN12	ENSSTOP00000006038	ENSSTOP00000020551	Receptor protein-tyrosine kinase.	Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.	0.814
EGFR	PTPN22	ENSSTOP00000006038	ENSSTOP00000013156	Receptor protein-tyrosine kinase.	Protein tyrosine phosphatase non-receptor type 22.	0.814
EGFR	PXN	ENSSTOP00000006038	ENSSTOP00000012629	Receptor protein-tyrosine kinase.	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.	0.632
EGFR	SRC	ENSSTOP00000006038	ENSSTOP00000014871	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.990