PCSK1N protein (Ictidomys tridecemlineatus) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

PCSK1N

Proprotein convertase subtilisin/kexin type 1 inhibitor. (261 aa)

Predicted Functional Partners:

PCSK1

0.529

GPR171

0.522

CPE

0.518

NMB

0.450

NPTXR

0.434

SCG2

0.421

CHGB

0.419

LOC101971842

0.408

QRFP

0.408

NPFF

0.408

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHGB	NMB	ENSSTOP00000021648	ENSSTOP00000001557	Chromogranin B.	Neuromedin B.	0.557
CHGB	NPFF	ENSSTOP00000021648	ENSSTOP00000028055	Chromogranin B.	Neuropeptide FF-amide peptide precursor.	0.426
CHGB	PCSK1	ENSSTOP00000021648	ENSSTOP00000009384	Chromogranin B.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.450
CHGB	PCSK1N	ENSSTOP00000021648	ENSSTOP00000023433	Chromogranin B.	Proprotein convertase subtilisin/kexin type 1 inhibitor.	0.419
CHGB	QRFP	ENSSTOP00000021648	ENSSTOP00000024292	Chromogranin B.	Pyroglutamylated RFamide peptide.	0.408
CHGB	SCG2	ENSSTOP00000021648	ENSSTOP00000020100	Chromogranin B.	Secretogranin II.	0.901
CPE	PCSK1	ENSSTOP00000011005	ENSSTOP00000009384	Carboxypeptidase E.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.544
CPE	PCSK1N	ENSSTOP00000011005	ENSSTOP00000023433	Carboxypeptidase E.	Proprotein convertase subtilisin/kexin type 1 inhibitor.	0.518
CPE	SCG2	ENSSTOP00000011005	ENSSTOP00000020100	Carboxypeptidase E.	Secretogranin II.	0.498
GPR171	PCSK1N	ENSSTOP00000021265	ENSSTOP00000023433	G protein-coupled receptor 171; Belongs to the G-protein coupled receptor 1 family.	Proprotein convertase subtilisin/kexin type 1 inhibitor.	0.522
LOC101971842	PCSK1N	ENSSTOP00000022186	ENSSTOP00000023433	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Proprotein convertase subtilisin/kexin type 1 inhibitor.	0.408
LOC101971842	QRFP	ENSSTOP00000022186	ENSSTOP00000024292	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Pyroglutamylated RFamide peptide.	0.517
NMB	CHGB	ENSSTOP00000001557	ENSSTOP00000021648	Neuromedin B.	Chromogranin B.	0.557
NMB	NPFF	ENSSTOP00000001557	ENSSTOP00000028055	Neuromedin B.	Neuropeptide FF-amide peptide precursor.	0.469
NMB	PCSK1N	ENSSTOP00000001557	ENSSTOP00000023433	Neuromedin B.	Proprotein convertase subtilisin/kexin type 1 inhibitor.	0.450
NMB	QRFP	ENSSTOP00000001557	ENSSTOP00000024292	Neuromedin B.	Pyroglutamylated RFamide peptide.	0.429
NPFF	CHGB	ENSSTOP00000028055	ENSSTOP00000021648	Neuropeptide FF-amide peptide precursor.	Chromogranin B.	0.426
NPFF	NMB	ENSSTOP00000028055	ENSSTOP00000001557	Neuropeptide FF-amide peptide precursor.	Neuromedin B.	0.469
NPFF	PCSK1N	ENSSTOP00000028055	ENSSTOP00000023433	Neuropeptide FF-amide peptide precursor.	Proprotein convertase subtilisin/kexin type 1 inhibitor.	0.408
NPFF	QRFP	ENSSTOP00000028055	ENSSTOP00000024292	Neuropeptide FF-amide peptide precursor.	Pyroglutamylated RFamide peptide.	0.632

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

4

average node degree:

1.6

avg. local clustering coefficient:

0.8

expected number of edges:

4

PPI enrichment p-value:

0.569

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042060

Wound healing

4 of 152

2.08

2.31

0.00013

GO:0007596

Blood coagulation

3 of 84

2.21

1.76

0.0017

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004252

Serine-type endopeptidase activity

3 of 201

1.83

1.01

0.0225

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17743

Mixed, incl. Fibronectin type II domain, and Establishment of epithelial cell apical/basal polarity

3 of 5

3.44

3.88

1.81e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0420

Kringle

3 of 20

2.83

3.6

3.42e-06

KW-0245

EGF-like domain

3 of 257

1.72

1.44

0.0027

KW-0964

Secreted

3 of 296

1.66

1.39

0.0028

KW-0720

Serine protease

2 of 88

2.01

1.24

0.0105

KW-1015

Disulfide bond

4 of 1497

1.08

0.78

0.0102

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038178

Kringle superfamily

3 of 20

2.83

2.72

8.08e-05

IPR000001

Kringle

3 of 20

2.83

2.72

8.08e-05

IPR013806

Kringle-like fold

3 of 33

2.62

2.59

0.00011

IPR018114

Serine proteases, trypsin family, histidine active site

3 of 99

2.14

1.71

0.0019

IPR001314

Peptidase S1A, chymotrypsin family

3 of 111

2.09

1.65

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00130

Kringle domain

3 of 20

2.83

3.35

8.45e-06

SM00020

Trypsin-like serine protease

3 of 137

2.0

1.78

0.0011

SM00181

Epidermal growth factor-like domain.

3 of 255

1.73

1.34

0.0044

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