STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PrlUncharacterized protein. (227 aa)    
Predicted Functional Partners:
PRLR
Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.
    
 0.993
CRLF1
Cytokine receptor like factor 1.
    
 0.924
LOC101969021
Uncharacterized protein.
   
0.897
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]
     
 0.880
JAK2
Tyrosine-protein kinase.
     
 0.876
GHR
Growth hormone receptor.
     
 0.872
LEPR
Leptin receptor.
     
 0.867
IFNAR1
Interferon alpha and beta receptor subunit 1.
  
  
  0.838
EGFR
Receptor protein-tyrosine kinase.
     
 0.836
JAK3
Tyrosine-protein kinase.
     
 0.828
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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