TGFA protein (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TGFA

Transforming growth factor alpha. (159 aa)

Predicted Functional Partners:

EGFR

0.995

ERBB4

0.974

ERBB2

0.974

ERBB3

0.974

IGF1

0.914

IDE

0.908

IGF1R

0.880

KDR

0.880

NTRK1

0.875

KIT

0.873

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSSTOP00000006038	ENSSTOP00000003374	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
EGFR	ERBB3	ENSSTOP00000006038	ENSSTOP00000023609	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.995
EGFR	ERBB4	ENSSTOP00000006038	ENSSTOP00000000168	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.986
EGFR	IGF1	ENSSTOP00000006038	ENSSTOP00000029785	Receptor protein-tyrosine kinase.	Insulin like growth factor 1.	0.927
EGFR	IGF1R	ENSSTOP00000006038	ENSSTOP00000010241	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.959
EGFR	KDR	ENSSTOP00000006038	ENSSTOP00000014480	Receptor protein-tyrosine kinase.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.750
EGFR	KIT	ENSSTOP00000006038	ENSSTOP00000000677	Receptor protein-tyrosine kinase.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.857
EGFR	NTRK1	ENSSTOP00000006038	ENSSTOP00000007027	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.668
EGFR	TGFA	ENSSTOP00000006038	ENSSTOP00000024749	Receptor protein-tyrosine kinase.	Transforming growth factor alpha.	0.995
ERBB2	EGFR	ENSSTOP00000003374	ENSSTOP00000006038	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
ERBB2	ERBB3	ENSSTOP00000003374	ENSSTOP00000023609	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.997
ERBB2	ERBB4	ENSSTOP00000003374	ENSSTOP00000000168	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.992
ERBB2	IGF1	ENSSTOP00000003374	ENSSTOP00000029785	Receptor protein-tyrosine kinase.	Insulin like growth factor 1.	0.928
ERBB2	IGF1R	ENSSTOP00000003374	ENSSTOP00000010241	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.969
ERBB2	KDR	ENSSTOP00000003374	ENSSTOP00000014480	Receptor protein-tyrosine kinase.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.668
ERBB2	KIT	ENSSTOP00000003374	ENSSTOP00000000677	Receptor protein-tyrosine kinase.	Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.732
ERBB2	NTRK1	ENSSTOP00000003374	ENSSTOP00000007027	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.691
ERBB2	TGFA	ENSSTOP00000003374	ENSSTOP00000024749	Receptor protein-tyrosine kinase.	Transforming growth factor alpha.	0.974
ERBB3	EGFR	ENSSTOP00000023609	ENSSTOP00000006038	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.995
ERBB3	ERBB2	ENSSTOP00000023609	ENSSTOP00000003374	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.997