STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NRG4Neuregulin 4. (123 aa)    
Predicted Functional Partners:
ERBB4
Receptor protein-tyrosine kinase.
    
 0.953
NRG2
Neuregulin 2.
    
 0.946
ERBB3
Erb-b2 receptor tyrosine kinase 3.
    
 0.937
NRG1
Neuregulin 1.
    
 0.936
EGFR
Receptor protein-tyrosine kinase.
    
 0.874
ERBB2
Receptor protein-tyrosine kinase.
    
 0.849
H6PD
Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.
   
 
 0.823
LOC101964641
Uncharacterized protein.
     
 0.822
ENSSTOP00000030902
Uncharacterized protein.
     
 0.822
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.742
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.