LOC101976322 protein (Ictidomys tridecemlineatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

LOC101976322

Uncharacterized protein. (604 aa)

Predicted Functional Partners:

APP

0.983

APLP2

0.830

APLP1

0.814

MRE11

0.687

MAPK10

0.657

MAPK8

0.657

KAT8

0.648

KAT7

0.648

KAT5

0.648

Rad50

0.628

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLP1	APLP2	ENSSTOP00000023431	ENSSTOP00000009021	Amyloid beta precursor like protein 1.	Amyloid beta precursor like protein 2.	0.413
APLP1	APP	ENSSTOP00000023431	ENSSTOP00000026933	Amyloid beta precursor like protein 1.	Amyloid beta precursor protein.	0.415
APLP1	LOC101976322	ENSSTOP00000023431	ENSSTOP00000026464	Amyloid beta precursor like protein 1.	Uncharacterized protein.	0.814
APLP2	APLP1	ENSSTOP00000009021	ENSSTOP00000023431	Amyloid beta precursor like protein 2.	Amyloid beta precursor like protein 1.	0.413
APLP2	APP	ENSSTOP00000009021	ENSSTOP00000026933	Amyloid beta precursor like protein 2.	Amyloid beta precursor protein.	0.648
APLP2	LOC101976322	ENSSTOP00000009021	ENSSTOP00000026464	Amyloid beta precursor like protein 2.	Uncharacterized protein.	0.830
APP	APLP1	ENSSTOP00000026933	ENSSTOP00000023431	Amyloid beta precursor protein.	Amyloid beta precursor like protein 1.	0.415
APP	APLP2	ENSSTOP00000026933	ENSSTOP00000009021	Amyloid beta precursor protein.	Amyloid beta precursor like protein 2.	0.648
APP	KAT5	ENSSTOP00000026933	ENSSTOP00000028998	Amyloid beta precursor protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.879
APP	KAT7	ENSSTOP00000026933	ENSSTOP00000028718	Amyloid beta precursor protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.515
APP	KAT8	ENSSTOP00000026933	ENSSTOP00000000580	Amyloid beta precursor protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.515
APP	LOC101976322	ENSSTOP00000026933	ENSSTOP00000026464	Amyloid beta precursor protein.	Uncharacterized protein.	0.983
APP	MAPK10	ENSSTOP00000026933	ENSSTOP00000001622	Amyloid beta precursor protein.	Mitogen-activated protein kinase.	0.454
KAT5	APP	ENSSTOP00000028998	ENSSTOP00000026933	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Amyloid beta precursor protein.	0.879
KAT5	LOC101976322	ENSSTOP00000028998	ENSSTOP00000026464	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Uncharacterized protein.	0.648
KAT5	MRE11	ENSSTOP00000028998	ENSSTOP00000024452	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.652
KAT5	Rad50	ENSSTOP00000028998	ENSSTOP00000008870	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Zinc-hook domain-containing protein.	0.673
KAT7	APP	ENSSTOP00000028718	ENSSTOP00000026933	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Amyloid beta precursor protein.	0.515
KAT7	LOC101976322	ENSSTOP00000028718	ENSSTOP00000026464	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Uncharacterized protein.	0.648
KAT7	MRE11	ENSSTOP00000028718	ENSSTOP00000024452	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.650

page 1 of 3

Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.8

expected number of edges:

8

PPI enrichment p-value:

0.412

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

4 of 30

2.45

2.86

3.49e-06

GO:0040031

snRNA modification

3 of 8

2.9

2.63

1.54e-05

GO:0008380

RNA splicing

6 of 351

1.55

1.92

9.26e-06

GO:0000398

mRNA splicing, via spliceosome

5 of 229

1.66

1.86

4.08e-05

GO:0016071

mRNA metabolic process

7 of 575

1.41

1.78

3.85e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017069

snRNA binding

7 of 39

2.58

6.59

6.85e-14

GO:0017070

U6 snRNA binding

4 of 8

3.02

4.21

1.86e-08

GO:0003723

RNA binding

9 of 1208

1.19

1.57

1.37e-07

GO:0097322

7SK snRNA binding

2 of 5

2.92

1.46

0.0023

GO:1901363

Heterocyclic compound binding

10 of 6430

0.51

0.37

0.0105

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030532

Small nuclear ribonucleoprotein complex

5 of 59

2.25

3.5

8.06e-08

GO:0046540

U4/U6 x U5 tri-snRNP complex

4 of 32

2.42

3.19

6.88e-07

GO:0015030

Cajal body

4 of 36

2.37

3.17

6.88e-07

GO:0071005

U2-type precatalytic spliceosome

4 of 48

2.24

2.95

1.35e-06

GO:1990904

Ribonucleoprotein complex

7 of 598

1.39

1.89

6.88e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19743

Regulation of protein localization to Cajal body, and U6 snRNA 3-end binding

4 of 6

3.15

4.14

2.82e-08

CL:18977

Small nuclear ribonucleoprotein complex, and snRNA binding

5 of 66

2.2

3.24

2.60e-07

CL:19047

Spliceosomal tri-snRNP complex assembly, and U4/U6 x U5 tri-snRNP complex

3 of 10

2.8

2.65

1.34e-05

CL:18979

Spliceosomal snRNP complex, and snRNA binding

4 of 60

2.15

2.46

1.20e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

4 of 266

1.5

1.26

0.0011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 391

1.43

1.31

0.00051

MAP-8953854

Metabolism of RNA

7 of 946

1.19

1.21

9.46e-05

MAP-72163

mRNA Splicing - Major Pathway

4 of 272

1.49

1.09

0.0034

MAP-72172

mRNA Splicing

4 of 296

1.45

1.06

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

7 of 447

1.52

2.16

5.13e-07

GOCC:0005634

Nucleus

8 of 3501

0.68

0.43

0.0232

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