STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)    
Predicted Functional Partners:
PRKAR2B
Protein kinase cAMP-dependent type II regulatory subunit beta.
 
 
 0.991
PKIA
cAMP-dependent protein kinase inhibitor; Belongs to the PKI family.
   
 0.988
PRKAR1B
Protein kinase cAMP-dependent type I regulatory subunit beta.
 
 
 0.978
PRKAR2A
Protein kinase cAMP-dependent type II regulatory subunit alpha.
 
 
 0.977
RYR2
Ryanodine receptor 2.
    
 0.976
PRKAR1A
Protein kinase cAMP-dependent type I regulatory subunit alpha.
 
 
 0.967
I3MMQ2_ICTTR
Uncharacterized protein.
 
 
 0.962
PLN
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
 0.961
CREB1
cAMP responsive element binding protein 1.
    
 0.941
GSK3B
Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.
   
0.939
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.