node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTG2 | CCBE1 | ENSSTOP00000012878 | ENSSTOP00000027124 | Actin gamma 2, smooth muscle. | Collagen and calcium binding EGF domains 1. | 0.600 |
ACTG2 | SPECC1 | ENSSTOP00000012878 | ENSSTOP00000029565 | Actin gamma 2, smooth muscle. | Sperm antigen with calponin homology and coiled-coil domains 1. | 0.469 |
ACTG2 | SUCLG2 | ENSSTOP00000012878 | ENSSTOP00000015828 | Actin gamma 2, smooth muscle. | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.562 |
CCBE1 | ACTG2 | ENSSTOP00000027124 | ENSSTOP00000012878 | Collagen and calcium binding EGF domains 1. | Actin gamma 2, smooth muscle. | 0.600 |
CCBE1 | SPECC1 | ENSSTOP00000027124 | ENSSTOP00000029565 | Collagen and calcium binding EGF domains 1. | Sperm antigen with calponin homology and coiled-coil domains 1. | 0.469 |
CCBE1 | SUCLG2 | ENSSTOP00000027124 | ENSSTOP00000015828 | Collagen and calcium binding EGF domains 1. | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.563 |
CHD8 | HDAC2 | ENSSTOP00000031649 | ENSSTOP00000011457 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.525 |
CHD8 | SPECC1 | ENSSTOP00000031649 | ENSSTOP00000029565 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | Sperm antigen with calponin homology and coiled-coil domains 1. | 0.568 |
HDAC2 | CHD8 | ENSSTOP00000011457 | ENSSTOP00000031649 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | 0.525 |
HDAC2 | SPECC1 | ENSSTOP00000011457 | ENSSTOP00000029565 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | Sperm antigen with calponin homology and coiled-coil domains 1. | 0.554 |
LOC101968893 | SPECC1 | ENSSTOP00000013292 | ENSSTOP00000029565 | Uncharacterized protein. | Sperm antigen with calponin homology and coiled-coil domains 1. | 0.408 |
OXSR1 | SPECC1 | ENSSTOP00000020732 | ENSSTOP00000029565 | Oxidative stress responsive kinase 1. | Sperm antigen with calponin homology and coiled-coil domains 1. | 0.418 |
PRSS57 | SH2D3C | ENSSTOP00000007845 | ENSSTOP00000008064 | Serine protease 57; Belongs to the peptidase S1 family. | SH2 domain containing 3C. | 0.681 |
PRSS57 | SPECC1 | ENSSTOP00000007845 | ENSSTOP00000029565 | Serine protease 57; Belongs to the peptidase S1 family. | Sperm antigen with calponin homology and coiled-coil domains 1. | 0.485 |
SH2D3C | PRSS57 | ENSSTOP00000008064 | ENSSTOP00000007845 | SH2 domain containing 3C. | Serine protease 57; Belongs to the peptidase S1 family. | 0.681 |
SH2D3C | SPECC1 | ENSSTOP00000008064 | ENSSTOP00000029565 | SH2 domain containing 3C. | Sperm antigen with calponin homology and coiled-coil domains 1. | 0.602 |
SPECC1 | ACTG2 | ENSSTOP00000029565 | ENSSTOP00000012878 | Sperm antigen with calponin homology and coiled-coil domains 1. | Actin gamma 2, smooth muscle. | 0.469 |
SPECC1 | CCBE1 | ENSSTOP00000029565 | ENSSTOP00000027124 | Sperm antigen with calponin homology and coiled-coil domains 1. | Collagen and calcium binding EGF domains 1. | 0.469 |
SPECC1 | CHD8 | ENSSTOP00000029565 | ENSSTOP00000031649 | Sperm antigen with calponin homology and coiled-coil domains 1. | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] | 0.568 |
SPECC1 | HDAC2 | ENSSTOP00000029565 | ENSSTOP00000011457 | Sperm antigen with calponin homology and coiled-coil domains 1. | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.554 |