STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2019 aa)    
Predicted Functional Partners:
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.997
SCN1B
Sodium voltage-gated channel beta subunit 1.
    
 0.990
SCN4B
Sodium voltage-gated channel beta subunit 4.
    
 0.970
Fgf13
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 
 0.966
FGF12
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
    
 
 0.952
SCN2B
Sodium voltage-gated channel beta subunit 2.
   
 0.950
SCN7A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  
 
0.912
SCN9A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
  
 
0.890
CAMK2D
Calcium/calmodulin dependent protein kinase II delta.
    
 0.874
CAMK2B
Calcium/calmodulin dependent protein kinase II beta.
    
 0.868
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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