Shc2 protein (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Shc2

Uncharacterized protein. (581 aa)

Predicted Functional Partners:

ERBB4

0.936

ERBB2

0.936

EGFR

0.936

ERBB3

0.936

GRB2

0.932

NTRK2

0.912

INSR

0.909

MST1R

0.909

NTRK1

0.909

IGF1R

0.909

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSSTOP00000006038	ENSSTOP00000003374	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
EGFR	ERBB3	ENSSTOP00000006038	ENSSTOP00000023609	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.995
EGFR	ERBB4	ENSSTOP00000006038	ENSSTOP00000000168	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.986
EGFR	GRB2	ENSSTOP00000006038	ENSSTOP00000011345	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.996
EGFR	IGF1R	ENSSTOP00000006038	ENSSTOP00000010241	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.959
EGFR	INSR	ENSSTOP00000006038	ENSSTOP00000000977	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.893
EGFR	MST1R	ENSSTOP00000006038	ENSSTOP00000004005	Receptor protein-tyrosine kinase.	Macrophage stimulating 1 receptor.	0.962
EGFR	NTRK1	ENSSTOP00000006038	ENSSTOP00000007027	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.668
EGFR	NTRK2	ENSSTOP00000006038	ENSSTOP00000008008	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.748
EGFR	Shc2	ENSSTOP00000006038	ENSSTOP00000031140	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.936
ERBB2	EGFR	ENSSTOP00000003374	ENSSTOP00000006038	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
ERBB2	ERBB3	ENSSTOP00000003374	ENSSTOP00000023609	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.997
ERBB2	ERBB4	ENSSTOP00000003374	ENSSTOP00000000168	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.992
ERBB2	GRB2	ENSSTOP00000003374	ENSSTOP00000011345	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.993
ERBB2	IGF1R	ENSSTOP00000003374	ENSSTOP00000010241	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.969
ERBB2	INSR	ENSSTOP00000003374	ENSSTOP00000000977	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.913
ERBB2	MST1R	ENSSTOP00000003374	ENSSTOP00000004005	Receptor protein-tyrosine kinase.	Macrophage stimulating 1 receptor.	0.949
ERBB2	NTRK1	ENSSTOP00000003374	ENSSTOP00000007027	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.691
ERBB2	NTRK2	ENSSTOP00000003374	ENSSTOP00000008008	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.700
ERBB2	Shc2	ENSSTOP00000003374	ENSSTOP00000031140	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.936

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.879

expected number of edges:

14

PPI enrichment p-value:

5.11e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

6 of 12

1.81

2.66

5.30e-07

GO:0031564

Transcription antitermination

3 of 3

2.11

1.69

0.00052

GO:0006353

DNA-templated transcription, termination

3 of 3

2.11

1.69

0.00052

GO:0016070

RNA metabolic process

7 of 75

1.08

1.11

5.42e-05

GO:0010467

Gene expression

9 of 136

0.93

0.97

7.65e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 4

1.99

1.31

0.0028

GO:0003676

Nucleic acid binding

8 of 177

0.77

0.59

0.0028

GO:0140098

Catalytic activity, acting on RNA

4 of 48

1.03

0.58

0.0311

GO:0003723

RNA binding

4 of 62

0.92

0.49

0.0476

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

3 of 5

1.89

1.38

0.0017

GO:0032991

Protein-containing complex

4 of 77

0.83

0.48

0.0351

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:220

RNA polymerase, and Transcription antitermination

5 of 5

2.11

3.01

5.81e-07

CL:138

Ribonucleoprotein

6 of 46

1.23

1.34

3.47e-05

CL:135

Ribonucleoprotein, and Translation regulator activity

7 of 65

1.15

1.24

2.14e-05

CL:1312

Mixed, incl. PUA-like superfamily, and Polyol metabolic process

2 of 5

1.72

0.89

0.0167

CL:121

Translation, and RNA metabolic process

8 of 135

0.89

0.86

3.72e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

3 of 3

2.11

1.68

0.00056

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

3 of 23

1.23

0.78

0.0118

MAP-5663205

Infectious disease

3 of 24

1.21

0.77

0.0118

MAP-1643685

Disease

3 of 24

1.21

0.77

0.0118

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 4

1.99

1.57

0.00078

KW-0804

Transcription

5 of 22

1.47

1.56

9.16e-05

KW-0548

Nucleotidyltransferase

3 of 11

1.55

1.05

0.0052

KW-0889

Transcription antitermination

2 of 2

2.11

1.05

0.0107

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About