node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKL_0486 | CKL_1372 | CKL_0486 | CKL_1372 | GMP synthase. | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.564 |
CKL_0486 | CKL_3463 | CKL_0486 | CKL_3463 | GMP synthase. | Predicted hydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.505 |
CKL_0486 | CKL_3596 | CKL_0486 | CKL_3596 | GMP synthase. | Conserved hypothetical protein containing an uridine kinase domain. | 0.819 |
CKL_0486 | ispH | CKL_0486 | CKL_1567 | GMP synthase. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase-related protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.668 |
CKL_0486 | rpH | CKL_0486 | CKL_3464 | GMP synthase. | RpH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.839 |
CKL_0960 | CKL_1372 | CKL_0960 | CKL_1372 | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.480 |
CKL_0960 | CKL_3462 | CKL_0960 | CKL_3462 | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Predicted phosphoesterase. | 0.455 |
CKL_0960 | CKL_3463 | CKL_0960 | CKL_3463 | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Predicted hydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.864 |
CKL_0960 | ispH | CKL_0960 | CKL_1567 | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase-related protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.629 |
CKL_0960 | rpH | CKL_0960 | CKL_3464 | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | RpH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.904 |
CKL_1372 | CKL_0486 | CKL_1372 | CKL_0486 | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | GMP synthase. | 0.564 |
CKL_1372 | CKL_0960 | CKL_1372 | CKL_0960 | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.480 |
CKL_1372 | CKL_3463 | CKL_1372 | CKL_3463 | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Predicted hydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.624 |
CKL_1372 | CKL_3596 | CKL_1372 | CKL_3596 | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Conserved hypothetical protein containing an uridine kinase domain. | 0.520 |
CKL_1372 | guaA | CKL_1372 | CKL_0466 | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | GuaA; Catalyzes the synthesis of GMP from XMP. | 0.645 |
CKL_1372 | ispH | CKL_1372 | CKL_1567 | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase-related protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.866 |
CKL_1372 | rnr | CKL_1372 | CKL_3376 | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Rnr; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.650 |
CKL_1372 | rpH | CKL_1372 | CKL_3464 | Hypothetical protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | RpH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.795 |
CKL_3462 | CKL_0960 | CKL_3462 | CKL_0960 | Predicted phosphoesterase. | Bifunctional folate synthesis protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.455 |
CKL_3462 | CKL_3463 | CKL_3462 | CKL_3463 | Predicted phosphoesterase. | Predicted hydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.964 |