IF1G_10437 protein (Cordyceps javanica) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

IF1G_10437

Short-chain dehydrogenase. (701 aa)

Predicted Functional Partners:

IF1G_06805

0.895

IF1G_04436

0.887

IF1G_01676

0.805

IF1G_00699

0.805

IF1G_05348

0.804

IF1G_09242

0.790

IF1G_00234

0.739

IF1G_03366

0.739

IF1G_02005

0.739

IF1G_10872

0.723

Your Current Organism:

Cordyceps javanica

NCBI taxonomy Id: 43265
Other names: C. javanica, CBS 134.22, Cordyceps javanica (Frieder. & Bally) Kepler, B. Shrestha & Spatafora, 2017, Isaria javanica, Isaria javanicus, Paecilomyces javanica, Paecilomyces sp. ARSEF 3776, Paecilomyces sp. ARSEF 3778, Spicaria javanica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IF1G_00234	IF1G_00699	A0A545VEZ6	A0A545WD83	E3 ubiquitin-protein ligase.	Developmental regulator flbA.	0.642
IF1G_00234	IF1G_01676	A0A545VEZ6	A0A545VCK1	E3 ubiquitin-protein ligase.	Uncharacterized protein.	0.642
IF1G_00234	IF1G_06805	A0A545VEZ6	A0A545VY72	E3 ubiquitin-protein ligase.	Rho GTPase activator Rga.	0.681
IF1G_00234	IF1G_09242	A0A545VEZ6	A0A545URU0	E3 ubiquitin-protein ligase.	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily.	0.423
IF1G_00234	IF1G_10437	A0A545VEZ6	A0A545UN71	E3 ubiquitin-protein ligase.	Short-chain dehydrogenase.	0.739
IF1G_00234	IF1G_10872	A0A545VEZ6	A0A545ULR4	E3 ubiquitin-protein ligase.	Ankyrin repeat protein.	0.799
IF1G_00699	IF1G_00234	A0A545WD83	A0A545VEZ6	Developmental regulator flbA.	E3 ubiquitin-protein ligase.	0.642
IF1G_00699	IF1G_02005	A0A545WD83	A0A545W973	Developmental regulator flbA.	Cellular morphogenesis protein.	0.642
IF1G_00699	IF1G_03366	A0A545WD83	A0A545W5C8	Developmental regulator flbA.	Uncharacterized protein.	0.642
IF1G_00699	IF1G_04436	A0A545WD83	A0A545W3B3	Developmental regulator flbA.	G-protein coupled receptor.	0.625
IF1G_00699	IF1G_05348	A0A545WD83	A0A545VZY1	Developmental regulator flbA.	MFS transporter.	0.792
IF1G_00699	IF1G_09242	A0A545WD83	A0A545URU0	Developmental regulator flbA.	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily.	0.964
IF1G_00699	IF1G_10437	A0A545WD83	A0A545UN71	Developmental regulator flbA.	Short-chain dehydrogenase.	0.805
IF1G_00699	IF1G_10872	A0A545WD83	A0A545ULR4	Developmental regulator flbA.	Ankyrin repeat protein.	0.919
IF1G_01676	IF1G_00234	A0A545VCK1	A0A545VEZ6	Uncharacterized protein.	E3 ubiquitin-protein ligase.	0.642
IF1G_01676	IF1G_02005	A0A545VCK1	A0A545W973	Uncharacterized protein.	Cellular morphogenesis protein.	0.642
IF1G_01676	IF1G_03366	A0A545VCK1	A0A545W5C8	Uncharacterized protein.	Uncharacterized protein.	0.642
IF1G_01676	IF1G_04436	A0A545VCK1	A0A545W3B3	Uncharacterized protein.	G-protein coupled receptor.	0.625
IF1G_01676	IF1G_05348	A0A545VCK1	A0A545VZY1	Uncharacterized protein.	MFS transporter.	0.792
IF1G_01676	IF1G_09242	A0A545VCK1	A0A545URU0	Uncharacterized protein.	Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily.	0.964

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.919

expected number of edges:

35

PPI enrichment p-value:

0.021

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 68

1.48

1.78

1.36e-05

GO:0016310

Phosphorylation

7 of 184

1.12

1.16

4.83e-05

GO:0050896

Response to stimulus

10 of 420

0.91

0.95

4.44e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

6 of 74

1.45

1.67

2.45e-05

GO:0016772

Transferase activity, transferring phosphorus-containing groups

8 of 247

1.05

1.09

2.45e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4467

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and OmpR/PhoB-type DNA-binding domain

9 of 43

1.86

4.43

3.83e-13

CL:4485

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

5 of 10

2.24

3.67

3.02e-08

CL:4474

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and Histidine Phosphotransfer domain

6 of 25

1.92

3.34

1.38e-08

CL:4490

Histidine Phosphotransfer domain, and PAS fold-4

4 of 5

2.44

3.33

3.78e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 87

1.55

2.97

3.64e-11

KW-0418

Kinase

7 of 125

1.29

1.62

1.84e-06

KW-0175

Coiled coil

5 of 214

0.91

0.6

0.0127

KW-0808

Transferase

8 of 518

0.73

0.58

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 38

1.8

3.35

2.03e-09

IPR003594

Histidine kinase/HSP90-like ATPase

8 of 54

1.71

3.31

2.65e-10

IPR011006

CheY-like superfamily

9 of 70

1.65

3.28

3.84e-11

IPR001789

Signal transduction response regulator, receiver domain

9 of 70

1.65

3.28

3.84e-11

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 43

1.75

3.15

3.70e-09

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

9 of 70

1.65

3.47

3.00e-12

SM00387

Histidine kinase-like ATPases

8 of 56

1.69

3.43

4.05e-11

SM00388

His Kinase A (phosphoacceptor) domain

7 of 42

1.76

3.39

4.97e-10

SM00073

Histidine Phosphotransfer domain

3 of 9

2.06

2.05

8.08e-05

SM00091

PAS domain

5 of 49

1.55

1.95

6.43e-06

(more ...)

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