IF1G_08451 protein (Cordyceps javanica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IF1G_08451

Fungal specific transcription factor domain-containing protein. (771 aa)

Predicted Functional Partners:

IF1G_05160

0.786

IF1G_03770

0.775

IF1G_06263

0.775

IF1G_05477

0.613

IF1G_01851

0.580

IF1G_06219

0.576

IF1G_03746

0.571

IF1G_06487

0.570

IF1G_03515

0.570

IF1G_02396

0.570

Your Current Organism:

Cordyceps javanica

NCBI taxonomy Id: 43265
Other names: C. javanica, CBS 134.22, Cordyceps javanica (Frieder. & Bally) Kepler, B. Shrestha & Spatafora, 2017, Isaria javanica, Isaria javanicus, Paecilomyces javanica, Paecilomyces sp. ARSEF 3776, Paecilomyces sp. ARSEF 3778, Spicaria javanica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IF1G_01851	IF1G_02396	A0A545VD36	A0A545V9B3	Small nucleolar ribonucleoprotein complex component (Utp5).	EMG1/NEP1 methyltransferase.	0.993
IF1G_01851	IF1G_03515	A0A545VD36	A0A545V7U2	Small nucleolar ribonucleoprotein complex component (Utp5).	Protein SOF1.	0.996
IF1G_01851	IF1G_03746	A0A545VD36	A0A545V8F6	Small nucleolar ribonucleoprotein complex component (Utp5).	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.977
IF1G_01851	IF1G_05477	A0A545VD36	A0A545V1Q2	Small nucleolar ribonucleoprotein complex component (Utp5).	HEAT repeat protein.	0.993
IF1G_01851	IF1G_06219	A0A545VD36	A0A545VV13	Small nucleolar ribonucleoprotein complex component (Utp5).	Nucleolar protein NOP58.	0.999
IF1G_01851	IF1G_06487	A0A545VD36	A0A545UYF1	Small nucleolar ribonucleoprotein complex component (Utp5).	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.981
IF1G_01851	IF1G_08451	A0A545VD36	A0A545UUK6	Small nucleolar ribonucleoprotein complex component (Utp5).	Fungal specific transcription factor domain-containing protein.	0.580
IF1G_02396	IF1G_01851	A0A545V9B3	A0A545VD36	EMG1/NEP1 methyltransferase.	Small nucleolar ribonucleoprotein complex component (Utp5).	0.993
IF1G_02396	IF1G_03515	A0A545V9B3	A0A545V7U2	EMG1/NEP1 methyltransferase.	Protein SOF1.	0.999
IF1G_02396	IF1G_03746	A0A545V9B3	A0A545V8F6	EMG1/NEP1 methyltransferase.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.998
IF1G_02396	IF1G_05477	A0A545V9B3	A0A545V1Q2	EMG1/NEP1 methyltransferase.	HEAT repeat protein.	0.998
IF1G_02396	IF1G_06219	A0A545V9B3	A0A545VV13	EMG1/NEP1 methyltransferase.	Nucleolar protein NOP58.	0.997
IF1G_02396	IF1G_06487	A0A545V9B3	A0A545UYF1	EMG1/NEP1 methyltransferase.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.998
IF1G_02396	IF1G_08451	A0A545V9B3	A0A545UUK6	EMG1/NEP1 methyltransferase.	Fungal specific transcription factor domain-containing protein.	0.570
IF1G_03515	IF1G_01851	A0A545V7U2	A0A545VD36	Protein SOF1.	Small nucleolar ribonucleoprotein complex component (Utp5).	0.996
IF1G_03515	IF1G_02396	A0A545V7U2	A0A545V9B3	Protein SOF1.	EMG1/NEP1 methyltransferase.	0.999
IF1G_03515	IF1G_03746	A0A545V7U2	A0A545V8F6	Protein SOF1.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.998
IF1G_03515	IF1G_05477	A0A545V7U2	A0A545V1Q2	Protein SOF1.	HEAT repeat protein.	0.999
IF1G_03515	IF1G_06219	A0A545V7U2	A0A545VV13	Protein SOF1.	Nucleolar protein NOP58.	0.990
IF1G_03515	IF1G_06487	A0A545V7U2	A0A545UYF1	Protein SOF1.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.998

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.882

expected number of edges:

13

PPI enrichment p-value:

0.000185

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015937

Coenzyme A biosynthetic process

6 of 7

2.94

6.4

1.04e-12

GO:0009165

Nucleotide biosynthetic process

7 of 114

1.79

3.34

1.85e-09

GO:1901137

Carbohydrate derivative biosynthetic process

7 of 253

1.45

2.11

1.68e-07

GO:0018130

Heterocycle biosynthetic process

8 of 488

1.22

1.59

2.98e-07

GO:1901362

Organic cyclic compound biosynthetic process

8 of 608

1.13

1.34

1.49e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004594

Pantothenate kinase activity

2 of 2

3.01

1.15

0.0084

GO:0004140

dephospho-CoA kinase activity

2 of 3

2.83

1.15

0.0084

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14397

Coenzyme A biosynthetic process, and 2-deoxyribonucleotide biosynthetic process

7 of 18

2.6

6.61

7.14e-14

CL:14421

Coenzyme A biosynthesis

5 of 6

2.93

5.45

7.14e-11

CL:14398

2-deoxyribonucleotide biosynthetic process, and Queuine tRNA-ribosyltransferase

2 of 12

2.23

0.86

0.0258

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00770

Pantothenate and CoA biosynthesis

7 of 61

2.07

4.67

1.12e-11

map01100

Metabolic pathways

10 of 3183

0.5

0.4

0.0023

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-196783

Coenzyme A biosynthesis

5 of 6

2.93

5.3

1.38e-10

MAP-199220

Vitamin B5 (pantothenate) metabolism

5 of 44

2.06

3.08

2.81e-07

MAP-196849

Metabolism of water-soluble vitamins and cofactors

5 of 126

1.6

1.85

2.82e-05

MAP-196854

Metabolism of vitamins and cofactors

5 of 167

1.48

1.58

8.24e-05

MAP-1430728

Metabolism

8 of 2109

0.59

0.37

0.0295

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990143

CoA-synthesizing protein complex

3 of 3

3.01

2.67

1.40e-05

GOCC:0071513

Phosphopantothenoylcysteine decarboxylase complex

2 of 2

3.01

1.43

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

2 of 9

2.35

1.05

0.0117

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02441

Flavoprotein

2 of 3

2.83

1.13

0.0091

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036551

Flavin prenyltransferase-like

2 of 3

2.83

0.88

0.0256

IPR003382

Flavoprotein

2 of 3

2.83

0.88

0.0256

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