IF1G_07193 protein (Cordyceps javanica) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

IF1G_07193

Ras like protein. (379 aa)

Predicted Functional Partners:

IF1G_06805

0.998

IF1G_08094

0.956

IF1G_05541

0.900

IF1G_07960

0.884

IF1G_00426

0.861

IF1G_10252

0.857

IF1G_00396

0.851

IF1G_02216

0.812

IF1G_00370

0.812

IF1G_10872

0.799

Your Current Organism:

Cordyceps javanica

NCBI taxonomy Id: 43265
Other names: C. javanica, CBS 134.22, Cordyceps javanica (Frieder. & Bally) Kepler, B. Shrestha & Spatafora, 2017, Isaria javanica, Isaria javanicus, Paecilomyces javanica, Paecilomyces sp. ARSEF 3776, Paecilomyces sp. ARSEF 3778, Spicaria javanica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IF1G_00370	IF1G_00396	A0A545VFD5	A0A545VFF3	Rho-GTPase-activating protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.546
IF1G_00370	IF1G_02216	A0A545VFD5	A0A545VE41	Rho-GTPase-activating protein.	Small GTPase, Rho type.	0.981
IF1G_00370	IF1G_05541	A0A545VFD5	A0A545VZE2	Rho-GTPase-activating protein.	Rho GTPase activator (Lrg11).	0.508
IF1G_00370	IF1G_06805	A0A545VFD5	A0A545VY72	Rho-GTPase-activating protein.	Rho GTPase activator Rga.	0.758
IF1G_00370	IF1G_07193	A0A545VFD5	A0A545UXW1	Rho-GTPase-activating protein.	Ras like protein.	0.812
IF1G_00370	IF1G_07960	A0A545VFD5	A0A545VUB0	Rho-GTPase-activating protein.	Rho guanyl nucleotide exchange factor.	0.548
IF1G_00396	IF1G_00370	A0A545VFF3	A0A545VFD5	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Rho-GTPase-activating protein.	0.546
IF1G_00396	IF1G_02216	A0A545VFF3	A0A545VE41	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Small GTPase, Rho type.	0.983
IF1G_00396	IF1G_05541	A0A545VFF3	A0A545VZE2	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Rho GTPase activator (Lrg11).	0.701
IF1G_00396	IF1G_06805	A0A545VFF3	A0A545VY72	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Rho GTPase activator Rga.	0.733
IF1G_00396	IF1G_07193	A0A545VFF3	A0A545UXW1	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Ras like protein.	0.851
IF1G_00396	IF1G_07960	A0A545VFF3	A0A545VUB0	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Rho guanyl nucleotide exchange factor.	0.705
IF1G_00396	IF1G_08094	A0A545VFF3	A0A545UVN9	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Chitin-binding, domain 3.	0.575
IF1G_00396	IF1G_10252	A0A545VFF3	A0A545VM10	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Cytokinesis protein sepA.	0.713
IF1G_00396	IF1G_10872	A0A545VFF3	A0A545ULR4	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Ankyrin repeat protein.	0.830
IF1G_00426	IF1G_02216	A0A545WCH7	A0A545VE41	Rho-gdp dissociation inhibitor.	Small GTPase, Rho type.	0.919
IF1G_00426	IF1G_06805	A0A545WCH7	A0A545VY72	Rho-gdp dissociation inhibitor.	Rho GTPase activator Rga.	0.525
IF1G_00426	IF1G_07193	A0A545WCH7	A0A545UXW1	Rho-gdp dissociation inhibitor.	Ras like protein.	0.861
IF1G_02216	IF1G_00370	A0A545VE41	A0A545VFD5	Small GTPase, Rho type.	Rho-GTPase-activating protein.	0.981
IF1G_02216	IF1G_00396	A0A545VE41	A0A545VFF3	Small GTPase, Rho type.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.983

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Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

11 of 156

2.14

7.45

2.46e-20

GO:0006360

Transcription by RNA polymerase I

6 of 11

3.03

7.26

2.80e-14

GO:0006352

DNA-templated transcription, initiation

7 of 49

2.44

6.29

9.77e-14

GO:0006361

Transcription initiation from RNA polymerase I promoter

4 of 6

3.11

4.78

1.80e-09

GO:0001188

RNA polymerase I preinitiation complex assembly

3 of 5

3.07

3.24

1.23e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140223

General transcription initiation factor activity

3 of 15

2.59

2.05

0.00016

GO:0001181

RNA polymerase I general transcription initiation factor activity

2 of 2

3.29

1.68

0.00095

GO:0001179

RNA polymerase I general transcription initiation factor binding

2 of 2

3.29

1.68

0.00095

GO:0003899

DNA-directed 5-3 RNA polymerase activity

2 of 16

2.39

1.08

0.0103

GO:0008134

Transcription factor binding

3 of 105

1.74

1.05

0.0076

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055029

Nuclear DNA-directed RNA polymerase complex

8 of 66

2.37

6.79

2.27e-15

GO:0005675

Transcription factor TFIIH holo complex

4 of 7

3.05

4.74

1.92e-09

GO:0005736

RNA polymerase I complex

4 of 9

2.94

4.58

3.38e-09

GO:0000439

Transcription factor TFIIH core complex

3 of 6

2.99

3.48

4.24e-07

GO:0005730

Nucleolus

5 of 300

1.51

1.84

1.12e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1775

RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription Initiation

11 of 112

2.28

8.72

4.38e-22

CL:1939

RNA Polymerase III Transcription Initiation From Type 1 Promoter, and RNA polymerase I complex

6 of 25

2.67

6.09

1.55e-12

CL:1793

Transcription factor TFIIH holo complex, and RNA polymerase II general transcription initiation factor activity

5 of 14

2.84

5.43

6.24e-11

CL:1977

RNA polymerase I complex

4 of 5

3.19

4.8

1.76e-09

CL:1796

Transcription factor TFIIH holo complex

3 of 5

3.07

3.23

1.32e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pcan03020

RNA polymerase

2 of 18

2.33

1.21

0.0057

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73772

RNA Polymerase I Promoter Escape

11 of 25

2.93

14.18

7.24e-29

MAP-73864

RNA Polymerase I Transcription

11 of 33

2.81

13.4

4.62e-28

MAP-73854

RNA Polymerase I Promoter Clearance

11 of 33

2.81

13.4

4.62e-28

MAP-73762

RNA Polymerase I Transcription Initiation

10 of 25

2.89

12.59

1.18e-25

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

5 of 35

2.44

4.43

1.74e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

8 of 63

2.39

6.88

1.80e-15

GOCC:0032806

Carboxy-terminal domain protein kinase complex

4 of 12

2.81

4.19

1.54e-08

GOCC:0016591

RNA polymerase II, holoenzyme

4 of 35

2.35

3.22

4.94e-07

GOCC:0031981

Nuclear lumen

5 of 561

1.24

1.13

0.00053

GOCC:0005634

Nucleus

7 of 1786

0.88

0.75

0.00061

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

2 of 10

2.59

1.3

0.0042

KW-0548

Nucleotidyltransferase

2 of 17

2.36

1.23

0.0054

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06870

A49-like RNA polymerase I associated factor

2 of 2

3.29

1.49

0.0021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009668

RNA polymerase I associated factor, A49-like

2 of 2

3.29

1.24

0.0059

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