IF1G_01302 protein (Cordyceps javanica) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

IF1G_01302

Aspartokinase. (490 aa)

Predicted Functional Partners:

IF1G_08014

0.994

IF1G_05888

0.993

IF1G_08497

0.978

IF1G_10117

0.974

IF1G_02715

0.962

IF1G_06188

0.960

IF1G_02945

0.955

IF1G_11354

0.937

IF1G_03281

0.893

IF1G_00320

0.892

Your Current Organism:

Cordyceps javanica

NCBI taxonomy Id: 43265
Other names: C. javanica, CBS 134.22, Cordyceps javanica (Frieder. & Bally) Kepler, B. Shrestha & Spatafora, 2017, Isaria javanica, Isaria javanicus, Paecilomyces javanica, Paecilomyces sp. ARSEF 3776, Paecilomyces sp. ARSEF 3778, Spicaria javanica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IF1G_00320	IF1G_01302	A0A545VF84	A0A545VBH6	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Aspartokinase.	0.892
IF1G_00320	IF1G_02715	A0A545VF84	A0A545W766	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Histidine biosynthesis trifunctional protein.	0.928
IF1G_00320	IF1G_02945	A0A545VF84	A0A545W7U7	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Histidinol-phosphate aminotransferase.	0.825
IF1G_00320	IF1G_03281	A0A545VF84	A0A545V753	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Argininosuccinate synthase.	0.762
IF1G_00320	IF1G_05888	A0A545VF84	A0A545UZK5	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Homoserine dehydrogenase.	0.775
IF1G_00320	IF1G_06188	A0A545VF84	A0A545V0F9	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Threonine synthase.	0.588
IF1G_00320	IF1G_08014	A0A545VF84	A0A545VU11	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Aspartate-semialdehyde dehydrogenase.	0.742
IF1G_00320	IF1G_08497	A0A545VF84	A0A545VP02	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Tryptophan synthase.	0.999
IF1G_00320	IF1G_10117	A0A545VF84	A0A545VMP1	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Homoserine kinase.	0.568
IF1G_00320	IF1G_11354	A0A545VF84	A0A545VIB1	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Homoserine dehydrogenase.	0.775
IF1G_01302	IF1G_00320	A0A545VBH6	A0A545VF84	Aspartokinase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.892
IF1G_01302	IF1G_02715	A0A545VBH6	A0A545W766	Aspartokinase.	Histidine biosynthesis trifunctional protein.	0.962
IF1G_01302	IF1G_02945	A0A545VBH6	A0A545W7U7	Aspartokinase.	Histidinol-phosphate aminotransferase.	0.955
IF1G_01302	IF1G_03281	A0A545VBH6	A0A545V753	Aspartokinase.	Argininosuccinate synthase.	0.893
IF1G_01302	IF1G_05888	A0A545VBH6	A0A545UZK5	Aspartokinase.	Homoserine dehydrogenase.	0.993
IF1G_01302	IF1G_06188	A0A545VBH6	A0A545V0F9	Aspartokinase.	Threonine synthase.	0.960
IF1G_01302	IF1G_08014	A0A545VBH6	A0A545VU11	Aspartokinase.	Aspartate-semialdehyde dehydrogenase.	0.994
IF1G_01302	IF1G_08497	A0A545VBH6	A0A545VP02	Aspartokinase.	Tryptophan synthase.	0.978
IF1G_01302	IF1G_10117	A0A545VBH6	A0A545VMP1	Aspartokinase.	Homoserine kinase.	0.974
IF1G_01302	IF1G_11354	A0A545VBH6	A0A545VIB1	Aspartokinase.	Homoserine dehydrogenase.	0.937

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.894

expected number of edges:

14

PPI enrichment p-value:

0.000604

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006401

RNA catabolic process

4 of 12

2.05

2.0

0.00010

GO:0016070

RNA metabolic process

5 of 156

1.04

0.69

0.0104

GO:1901575

Organic substance catabolic process

5 of 225

0.88

0.49

0.0365

GO:0006139

Nucleobase-containing compound metabolic process

7 of 461

0.71

0.47

0.0168

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003724

RNA helicase activity

3 of 3

2.53

1.93

0.00027

GO:0004386

Helicase activity

4 of 21

1.81

1.69

0.00027

GO:0140657

ATP-dependent activity

5 of 135

1.1

0.81

0.0048

GO:0140098

Catalytic activity, acting on RNA

4 of 96

1.15

0.7

0.0166

GO:0140640

Catalytic activity, acting on a nucleic acid

5 of 174

0.99

0.65

0.0126

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30678639

(2019) Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation in Aspergillus oryzae 112822.

3 of 9

2.05

1.44

0.0016

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

7 of 28

1.93

3.99

1.37e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0347

Helicase

3 of 17

1.78

1.15

0.0047

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR014014

RNA helicase, DEAD-box type, Q motif

3 of 3

2.53

1.76

0.00055

IPR000629

ATP-dependent RNA helicase DEAD-box, conserved site

3 of 3

2.53

1.76

0.00055

IPR011545

DEAD/DEAH box helicase domain

3 of 8

2.11

1.47

0.0015

IPR014001

Helicase superfamily 1/2, ATP-binding domain

3 of 12

1.93

1.28

0.0031

IPR001650

Helicase, C-terminal

3 of 12

1.93

1.28

0.0031

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00487

DEAD-like helicases superfamily

4 of 13

2.02

2.41

1.01e-05

SM00490

Helicase superfamily c-terminal domain

4 of 15

1.96

2.36

1.01e-05

SM00316

Ribosomal protein S1-like RNA-binding domain

2 of 9

1.88

0.94

0.0153

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