IF1G_07527 protein (Cordyceps javanica) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

IF1G_07527

Uncharacterized protein. (569 aa)

Predicted Functional Partners:

IF1G_09596

0.708

IF1G_00484

0.632

IF1G_01896

0.595

IF1G_09728

0.595

IF1G_01762

0.595

IF1G_07631

0.592

IF1G_05828

0.566

IF1G_01340

0.566

IF1G_05735

0.553

IF1G_00008

0.552

Your Current Organism:

Cordyceps javanica

NCBI taxonomy Id: 43265
Other names: C. javanica, CBS 134.22, Cordyceps javanica (Frieder. & Bally) Kepler, B. Shrestha & Spatafora, 2017, Isaria javanica, Isaria javanicus, Paecilomyces javanica, Paecilomyces sp. ARSEF 3776, Paecilomyces sp. ARSEF 3778, Spicaria javanica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IF1G_00008	IF1G_01340	A0A545VEB9	A0A545VBL6	Ras family protein.	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation; Belongs to the adenylate kinase family. AK6 subfamily.	0.981
IF1G_00008	IF1G_05735	A0A545VEB9	A0A545VYX8	Ras family protein.	Serine/threonine-protein kinase plo1.	0.756
IF1G_00008	IF1G_07527	A0A545VEB9	A0A545VSD5	Ras family protein.	Uncharacterized protein.	0.552
IF1G_00484	IF1G_07527	A0A545VFQ6	A0A545VSD5	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	Uncharacterized protein.	0.632
IF1G_00484	IF1G_09596	A0A545VFQ6	A0A545UPY6	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.997
IF1G_01340	IF1G_00008	A0A545VBL6	A0A545VEB9	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation; Belongs to the adenylate kinase family. AK6 subfamily.	Ras family protein.	0.981
IF1G_01340	IF1G_01762	A0A545VBL6	A0A545W9V2	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation; Belongs to the adenylate kinase family. AK6 subfamily.	Transcription factor steA.	0.469
IF1G_01340	IF1G_01896	A0A545VBL6	A0A545VD80	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation; Belongs to the adenylate kinase family. AK6 subfamily.	Cutinase G-box binding protein.	0.469
IF1G_01340	IF1G_07527	A0A545VBL6	A0A545VSD5	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation; Belongs to the adenylate kinase family. AK6 subfamily.	Uncharacterized protein.	0.566
IF1G_01340	IF1G_09728	A0A545VBL6	A0A545VP90	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation; Belongs to the adenylate kinase family. AK6 subfamily.	Zinc finger protein odd-paired-like (Opl).	0.469
IF1G_01762	IF1G_01340	A0A545W9V2	A0A545VBL6	Transcription factor steA.	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation; Belongs to the adenylate kinase family. AK6 subfamily.	0.469
IF1G_01762	IF1G_07527	A0A545W9V2	A0A545VSD5	Transcription factor steA.	Uncharacterized protein.	0.595
IF1G_01896	IF1G_01340	A0A545VD80	A0A545VBL6	Cutinase G-box binding protein.	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation; Belongs to the adenylate kinase family. AK6 subfamily.	0.469
IF1G_01896	IF1G_07527	A0A545VD80	A0A545VSD5	Cutinase G-box binding protein.	Uncharacterized protein.	0.595
IF1G_05735	IF1G_00008	A0A545VYX8	A0A545VEB9	Serine/threonine-protein kinase plo1.	Ras family protein.	0.756
IF1G_05735	IF1G_05828	A0A545VYX8	A0A545V2P8	Serine/threonine-protein kinase plo1.	Checkpoint protein kinase (SldA).	0.981
IF1G_05735	IF1G_07527	A0A545VYX8	A0A545VSD5	Serine/threonine-protein kinase plo1.	Uncharacterized protein.	0.553
IF1G_05828	IF1G_05735	A0A545V2P8	A0A545VYX8	Checkpoint protein kinase (SldA).	Serine/threonine-protein kinase plo1.	0.981
IF1G_05828	IF1G_07527	A0A545V2P8	A0A545VSD5	Checkpoint protein kinase (SldA).	Uncharacterized protein.	0.566
IF1G_07527	IF1G_00008	A0A545VSD5	A0A545VEB9	Uncharacterized protein.	Ras family protein.	0.552

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.919

expected number of edges:

11

PPI enrichment p-value:

3.44e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032784

Regulation of DNA-templated transcription, elongation

7 of 21

2.45

5.84

1.21e-12

GO:0032786

Positive regulation of DNA-templated transcription, elongation

5 of 17

2.39

4.02

1.09e-08

GO:0006355

Regulation of transcription, DNA-templated

10 of 482

1.24

1.82

3.13e-09

GO:0006357

Regulation of transcription by RNA polymerase II

8 of 338

1.3

1.8

1.26e-07

GO:0006368

Transcription elongation from RNA polymerase II promoter

3 of 24

2.02

1.77

0.00030

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

3 of 16

2.2

1.44

0.0019

GO:0030332

Cyclin binding

2 of 6

2.45

1.01

0.0142

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

2 of 6

2.45

1.01

0.0142

GO:0004693

Cyclin-dependent protein serine/threonine kinase activity

2 of 9

2.27

0.94

0.0185

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008024

cyclin/CDK positive transcription elongation factor complex

4 of 4

2.92

4.16

2.13e-08

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

5 of 17

2.39

3.92

1.81e-08

GO:0008023

Transcription elongation factor complex

5 of 19

2.34

3.88

1.81e-08

GO:0070692

CTDK-1 complex

3 of 3

2.92

3.08

2.34e-06

GO:0061695

Transferase complex, transferring phosphorus-containing groups

6 of 124

1.61

2.36

3.63e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1146

Transcription elongation factor complex, and RNA polymerase II, core complex

10 of 39

2.33

8.19

1.21e-19

CL:1213

cyclin/CDK positive transcription elongation factor complex

5 of 5

2.92

5.5

5.75e-11

CL:1065

Mixed, incl. DNA-directed RNA polymerase complex, and Mediator complex

11 of 147

1.8

4.97

2.16e-17

CL:1154

RNA Polymerase II Transcription Elongation

5 of 23

2.26

3.78

1.90e-08

CL:1155

RNA polymerase II, core complex, and Transcription antitermination

4 of 14

2.38

3.22

5.49e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

9 of 41

2.26

6.95

9.66e-17

MAP-674695

RNA Polymerase II Pre-transcription Events

7 of 65

1.96

4.12

7.92e-11

MAP-3700989

Transcriptional Regulation by TP53

9 of 172

1.64

3.41

5.88e-12

MAP-212436

Generic Transcription Pathway

10 of 250

1.53

3.07

1.34e-12

MAP-113418

Formation of the Early Elongation Complex

4 of 32

2.02

2.44

8.51e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008023

Transcription elongation factor complex

8 of 25

2.43

6.98

1.71e-15

GOCC:0019908

Nuclear cyclin-dependent protein kinase holoenzyme complex

6 of 8

2.8

6.35

7.91e-13

GOCC:0008024

cyclin/CDK positive transcription elongation factor complex

5 of 6

2.84

5.35

9.36e-11

GOCC:0032044

DSIF complex

3 of 3

2.92

3.09

2.24e-06

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

7 of 139

1.63

2.78

7.32e-09

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

3 of 6

2.62

2.47

2.59e-05

KW-0251

Elongation factor

2 of 16

2.02

0.86

0.0240

KW-0804

Transcription

3 of 118

1.33

0.7

0.0275

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR043198

Cyclin/Cyclin-like subunit Ssn8

3 of 4

2.8

2.14

0.00012

IPR013763

Cyclin-like domain

3 of 8

2.5

1.91

0.00028

IPR006671

Cyclin, N-terminal

3 of 8

2.5

1.91

0.00028

IPR036915

Cyclin-like superfamily

3 of 12

2.32

1.81

0.00039

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

3 of 12

2.32

1.97

0.00018

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