STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A4U5QPZ3Werner Syndrome-like exonuclease. (323 aa)    
Predicted Functional Partners:
A0A4U5MB78
DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1.
   
 
 0.739
A0A4U5QEI6
Exonuclease 1.
   
 0.732
A0A4U5QKM3
Exonuclease 1.
   
 0.732
A0A4V6XX27
DNA repair protein XRCC3-like.
    
 0.691
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.683
A0A4U5QB38
Flap endonuclease GEN-like 2 isoform X4.
   
 0.683
A0A4U5QVA2
Uncharacterized protein.
   
 0.683
A0A4U5QAN1
Uncharacterized protein.
    
 0.678
A0A4U5N8N6
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.661
A0A4U5Q419
Uncharacterized protein.
    
 0.661
Your Current Organism:
Populus alba
NCBI taxonomy Id: 43335
Other names: P. alba, Populus alba L., abele, gin-doro, silver-leaf poplar, white poplar, xin bai yang
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