STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMAD7SMAD family member 7. (426 aa)    
Predicted Functional Partners:
SMURF2
SMAD specific E3 ubiquitin protein ligase 2.
    
 0.999
TGFBR1
Transforming growth factor beta receptor 1.
   
 0.998
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 0.997
RNF111
Ring finger protein 111.
   
 0.967
TGFBR2
Transforming growth factor beta receptor 2.
   
 0.965
YAP1
Yes associated protein 1.
    
 0.957
BAMBI
BMP and activin membrane bound inhibitor.
   
 0.952
SMAD5
SMAD family member 5.
   
0.951
SMAD2
SMAD family member 2.
   
0.943
NEDD4L
NEDD4 like E3 ubiquitin protein ligase.
    
 0.937
Your Current Organism:
Bison bison
NCBI taxonomy Id: 43346
Other names: B. bison bison, Bison bison bison, Bos bison bison
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.