STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (404 aa)    
Predicted Functional Partners:
iscU
FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 0.999
NRI_0295
Rrf2/aminotransferase, class V family protein; Identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF02082; match to protein family HMM TIGR00738.
 
 
0.994
NRI_0745
Molybdopterin biosynthesis protein MoeB; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.
   
 0.989
NRI_0288
Iron-sulfur cluster binding protein; Identified by match to protein family HMM PF00111.
 
 0.988
NRI_0292
Iron-sulfur cluster assembly accessory protein; Identified by match to protein family HMM PF01521; match to protein family HMM TIGR00049; Belongs to the HesB/IscA family.
  
  
 0.941
NRI_0290
Putative chaperone protein HscB; Identified by match to protein family HMM PF07743; Belongs to the HscB family.
  
 
 0.846
NRI_0291
Putative chaperone protein HscB.
  
 
 0.846
NRI_0427
Acyl carrier protein.
    
 
 0.810
NRI_0556
Conserved hypothetical protein; Identified by match to protein family HMM PF04384.
  
 
 0.688
NRI_0784
Hira-interacting protein 5; Identified by match to protein family HMM PF01106; match to protein family HMM PF08712.
  
 
 0.667
Your Current Organism:
Neorickettsia risticii
NCBI taxonomy Id: 434131
Other names: N. risticii str. Illinois, Neorickettsia risticii str. Illinois, Neorickettsia risticii strain Illinois
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.