STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiGThiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)    
Predicted Functional Partners:
thiS
Thiamine biosynthesis protein ThiS; Identified by match to protein family HMM PF02597; match to protein family HMM TIGR01683.
  
 
 0.999
NRI_0745
Molybdopterin biosynthesis protein MoeB; Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.
 
  
 0.970
NRI_0911
Phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543.
  
  
 0.872
NRI_0212
Putative thiamine-phosphate pyrophosphorylase; Identified by match to protein family HMM PF02581.
  
  
 0.808
NRI_0339
Thiamine monophosphate synthase/teni subfamily; Identified by match to protein family HMM PF02581.
  
  
 0.808
NRI_0004
Conserved hypothetical protein.
  
  
 0.640
NRI_0457
Hypothetical protein; Identified by Glimmer2; putative.
       0.551
NRI_0854
GMP synthase, glutamine-hydrolyzing; Identified by match to protein family HMM PF00117; match to protein family HMM PF00958; match to protein family HMM TIGR00884; match to protein family HMM TIGR00888.
     
 0.548
NRI_0651
DNA polymerase I; Identified by match to protein family HMM PF00476; match to protein family HMM PF01367; match to protein family HMM PF02739; match to protein family HMM TIGR00593.
   
  
 0.511
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
    
  0.503
Your Current Organism:
Neorickettsia risticii
NCBI taxonomy Id: 434131
Other names: N. risticii str. Illinois, Neorickettsia risticii str. Illinois, Neorickettsia risticii strain Illinois
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