STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NRI_0701Pentapeptide repeat domain protein; Identified by match to protein family HMM PF00805. (551 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.856
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
       0.762
NRI_0828
Type IV secretion system protein, VirB6 family; Identified by match to protein family HMM PF04610.
  
     0.720
NRI_0829
Type IV secretion system protein, VirB6 family; Identified by match to protein family HMM PF04610.
  
     0.720
NRI_0499
Conserved hypothetical protein.
 
     0.714
NRI_0700
Putative sodium:proline symporter; Identified by match to protein family HMM PF00474; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
       0.688
NRI_0794
Identified by match to protein family HMM PF00149.
 
     0.670
NRI_0857
Conserved hypothetical protein.
 
  
 0.650
NRI_0737
Type IV secretion system protein VirB4.
 
   
 0.648
NRI_0830
Type IV secretion system protein VirB6; Identified by match to protein family HMM PF04610.
  
     0.637
Your Current Organism:
Neorickettsia risticii
NCBI taxonomy Id: 434131
Other names: N. risticii str. Illinois, Neorickettsia risticii str. Illinois, Neorickettsia risticii strain Illinois
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.