Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
NRI_0705Citrate synthase; Identified by match to protein family HMM PF00285; Belongs to the citrate synthase family. (398 aa)    
Predicted Functional Partners:
acnA
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.999
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.998
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.990
NRI_0910
Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.983
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.970
sucA
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component; Identified by match to protein family HMM PF00676; match to protein family HMM PF02779; match to protein family HMM TIGR00239.
  
 0.961
NRI_0399
NADP-dependent malic enzyme, N-terminal fragment; Contains a authentic frameshift if combined with NRI_0400 (ORF00385) according to frameshift analysis. Identified by match to protein family HMM PF00390; match to protein family HMM PF03949.
  
 
 0.950
NRI_0400
NADP-dependent malic enzyme, C-terminal fragment; Contains a frameshift based on matches to NSE_0420, if combined with NRI_0399 (ORF00384).
  
 
 0.950
icd
Isocitrate dehydrogenase; Identified by match to protein family HMM PF00180; match to protein family HMM TIGR02924.
  
 0.932
NRI_0511
Succinate dehydrogenase and fumarate reductase iron-sulfur protein; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR00384.
  
 
 0.929
Your Current Organism:
Neorickettsia risticii
NCBI taxonomy Id: 434131
Other names: N. risticii str. Illinois, Neorickettsia risticii str. Illinois, Neorickettsia risticii strain Illinois
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