STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NRI_0853Glutathione-regulated potassium-efflux system protein; Identified by match to protein family HMM PF00999; match to protein family HMM PF02254; match to protein family HMM TIGR00932; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (578 aa)    
Predicted Functional Partners:
NRI_0852
Thiol-disulfide isomerase, thioredoxin family.
  
  
 0.788
NRI_0815
Mechanosensitive ion channel family protein; Identified by match to protein family HMM PF00924.
 
  
 0.745
NRI_0612
DNA-binding protein HU; Identified by match to protein family HMM PF00216; Belongs to the bacterial histone-like protein family.
   
 
 0.689
NRI_0162
Periplasmic serine protease, DO/DeqQ family; Identified by match to protein family HMM PF00089; match to protein family HMM PF00595; match to protein family HMM TIGR02037; Belongs to the peptidase S1C family.
 
   
 0.687
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.641
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
     
 0.601
NRI_0785
DnaJ domain protein; Identified by match to protein family HMM PF00226.
     
 0.601
gshB
Glutathione synthetase; Identified by match to protein family HMM PF02951; match to protein family HMM PF02955; match to protein family HMM PF08443; Belongs to the prokaryotic GSH synthase family.
  
  
 0.591
NRI_0192
Putative transporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
     
 0.584
NRI_0700
Putative sodium:proline symporter; Identified by match to protein family HMM PF00474; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
     
 0.567
Your Current Organism:
Neorickettsia risticii
NCBI taxonomy Id: 434131
Other names: N. risticii str. Illinois, Neorickettsia risticii str. Illinois, Neorickettsia risticii strain Illinois
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