STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpP-2Hypothetical protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (224 aa)    
Predicted Functional Partners:
clpX
ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 
 0.982
AQS85029.1
Clp protease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.786
hrcA
Heat-inducible transcriptional repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.785
AQS83486.1
ClpV1 family T6SS ATPase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ClpA/ClpB family.
  
 
 0.732
clpA
ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ClpA/ClpB family.
  
 
 0.731
clpB
ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.729
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 
 0.694
ribB
Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
   
 
 0.568
grpE
Nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...]
   
 
 0.544
AQS84025.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.536
Your Current Organism:
Acetobacter aceti
NCBI taxonomy Id: 435
Other names: A. aceti, ATCC 15973, Acetimonas aceti, Acetobacter (subgen. Acetobacter) aceti, Acetobacter aceti aceti, Acetobacter aceti orleanensis, Acetobacter aceti subsp. aceti, Acetobacter aceti var. muciparum, Acetobacter ketogenum, Acetobacter lafarianum, Bacillus aceticus, Bacteriopsis aceti, Bacterium aceti, Bacterium acetigenoidum, Bacterium hansenianum, CCUG 18122, CIP 103111, DSM 3508, ICMP 8807, IFO 14818, JCM 7641, Micrococcus aceti, Mycoderma aceti souches non visqueuses (membraneuses), NBRC 14818, NCCB 23001, NCIB 8621, NCIB:8621, NCIMB 8621
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