node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BVU_1693 | gcvT | BVU_1693 | BVU_3828 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
BVU_1693 | glyA | BVU_1693 | BVU_3341 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
BVU_1693 | purD | BVU_1693 | BVU_1095 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.878 |
BVU_1693 | purE | BVU_1693 | BVU_1416 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.825 |
BVU_1693 | purH | BVU_1693 | BVU_1821 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase. | 0.900 |
BVU_1693 | purL | BVU_1693 | BVU_0078 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | Putative phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.959 |
BVU_1693 | purN | BVU_1693 | BVU_1052 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.982 |
BVU_1693 | purT | BVU_1693 | BVU_2768 | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.960 |
BVU_2623 | glyA | BVU_2623 | BVU_3341 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.442 |
BVU_2623 | purN | BVU_2623 | BVU_1052 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
BVU_2623 | purT | BVU_2623 | BVU_2768 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.909 |
gcvT | BVU_1693 | BVU_3828 | BVU_1693 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | 0.929 |
gcvT | glyA | BVU_3828 | BVU_3341 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
gcvT | purH | BVU_3828 | BVU_1821 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase. | 0.929 |
gcvT | purN | BVU_3828 | BVU_1052 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.928 |
gcvT | purT | BVU_3828 | BVU_2768 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.909 |
gcvT | purU | BVU_3828 | BVU_3850 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.924 |
glyA | BVU_1693 | BVU_3341 | BVU_1693 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional purine biosynthesis protein, putative 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase. | 0.972 |
glyA | BVU_2623 | BVU_3341 | BVU_2623 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.442 |
glyA | gcvT | BVU_3341 | BVU_3828 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.996 |