node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDI_0204 | BDI_3647 | BDI_0204 | BDI_3647 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Putative formiminotransferase-cyclodeaminase. | 0.920 |
BDI_0204 | folD | BDI_0204 | BDI_0219 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.927 |
BDI_0204 | purN | BDI_0204 | BDI_2826 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.915 |
BDI_1777 | folD | BDI_1777 | BDI_0219 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.927 |
BDI_1777 | gcvT | BDI_1777 | BDI_0312 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Putative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
BDI_1777 | glyA | BDI_1777 | BDI_1271 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.941 |
BDI_1777 | thyA | BDI_1777 | BDI_3749 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.923 |
BDI_3647 | BDI_0204 | BDI_3647 | BDI_0204 | Putative formiminotransferase-cyclodeaminase. | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.920 |
BDI_3647 | fhs | BDI_3647 | BDI_1014 | Putative formiminotransferase-cyclodeaminase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.927 |
BDI_3647 | fmt | BDI_3647 | BDI_1742 | Putative formiminotransferase-cyclodeaminase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
BDI_3647 | folD | BDI_3647 | BDI_0219 | Putative formiminotransferase-cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.927 |
BDI_3647 | gcvT | BDI_3647 | BDI_0312 | Putative formiminotransferase-cyclodeaminase. | Putative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.928 |
BDI_3647 | purH | BDI_3647 | BDI_1885 | Putative formiminotransferase-cyclodeaminase. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase. | 0.909 |
BDI_3647 | purN | BDI_3647 | BDI_2826 | Putative formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.910 |
fhs | BDI_3647 | BDI_1014 | BDI_3647 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative formiminotransferase-cyclodeaminase. | 0.927 |
fhs | folD | BDI_1014 | BDI_0219 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.993 |
fhs | gcvT | BDI_1014 | BDI_0312 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.940 |
fhs | glyA | BDI_1014 | BDI_1271 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.968 |
fhs | purH | BDI_1014 | BDI_1885 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase. | 0.979 |
fhs | purN | BDI_1014 | BDI_2826 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.962 |