node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDI_0415 | BDI_3645 | BDI_0415 | BDI_3645 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formiminotransferase-cyclodeaminase. | 0.900 |
BDI_0415 | BDI_3647 | BDI_0415 | BDI_3647 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative formiminotransferase-cyclodeaminase. | 0.418 |
BDI_0415 | BDI_3748 | BDI_0415 | BDI_3748 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.917 |
BDI_0415 | fhs | BDI_0415 | BDI_1014 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.940 |
BDI_0415 | folD | BDI_0415 | BDI_0219 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.532 |
BDI_0415 | gcvT | BDI_0415 | BDI_0312 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Putative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.944 |
BDI_0415 | glyA | BDI_0415 | BDI_1271 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
BDI_0415 | purH | BDI_0415 | BDI_1885 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase. | 0.914 |
BDI_0415 | purN | BDI_0415 | BDI_2826 | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
BDI_3645 | BDI_0415 | BDI_3645 | BDI_0415 | Formiminotransferase-cyclodeaminase. | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
BDI_3645 | BDI_3647 | BDI_3645 | BDI_3647 | Formiminotransferase-cyclodeaminase. | Putative formiminotransferase-cyclodeaminase. | 0.999 |
BDI_3645 | BDI_3748 | BDI_3645 | BDI_3748 | Formiminotransferase-cyclodeaminase. | Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.900 |
BDI_3645 | fhs | BDI_3645 | BDI_1014 | Formiminotransferase-cyclodeaminase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.909 |
BDI_3645 | folD | BDI_3645 | BDI_0219 | Formiminotransferase-cyclodeaminase. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.907 |
BDI_3645 | gcvT | BDI_3645 | BDI_0312 | Formiminotransferase-cyclodeaminase. | Putative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.904 |
BDI_3645 | glyA | BDI_3645 | BDI_1271 | Formiminotransferase-cyclodeaminase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
BDI_3645 | purH | BDI_3645 | BDI_1885 | Formiminotransferase-cyclodeaminase. | Phosphoribosylaminoimidazole carboxy formyl formyltransferase. | 0.900 |
BDI_3645 | purN | BDI_3645 | BDI_2826 | Formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.900 |
BDI_3647 | BDI_0415 | BDI_3647 | BDI_0415 | Putative formiminotransferase-cyclodeaminase. | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.418 |
BDI_3647 | BDI_3645 | BDI_3647 | BDI_3645 | Putative formiminotransferase-cyclodeaminase. | Formiminotransferase-cyclodeaminase. | 0.999 |