A0A166FI86 protein (Fibularhizoctonia sp. CBS109695)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

A0A166FI86

Protein kinase domain-containing protein. (1457 aa)

Predicted Functional Partners:

A0A166U8C4

0.956

A0A166P5Y2

0.946

A0A166XFB5

0.946

A0A166PZ83

0.908

A0A166WWM7

0.904

A0A166HDY0

0.896

A0A166WUU7

0.896

A0A166W4W6

0.869

A0A167WT60

0.869

A0A167WT30

0.868

Your Current Organism:

Fibularhizoctonia sp. CBS109695

NCBI taxonomy Id: 436010
Other names: F. sp. CBS 109695, Fibularhizoctonia sp. CBS 109695, Fibulorhizoctonia sp. CBS 109695

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A166FI86	A0A166HDY0	Protein kinase domain-containing protein.	Kinase-like protein.	0.896
A0A166FI86	A0A166P5Y2	Protein kinase domain-containing protein.	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	0.946
A0A166FI86	A0A166PZ83	Protein kinase domain-containing protein.	Uncharacterized protein.	0.908
A0A166FI86	A0A166U8C4	Protein kinase domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.956
A0A166FI86	A0A166W4W6	Protein kinase domain-containing protein.	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	0.869
A0A166FI86	A0A166WUU7	Protein kinase domain-containing protein.	Kinase-like protein.	0.896
A0A166FI86	A0A166WWM7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.904
A0A166FI86	A0A166XFB5	Protein kinase domain-containing protein.	Kinase-like protein.	0.946
A0A166FI86	A0A167WT30	Protein kinase domain-containing protein.	Kinase-like protein.	0.868
A0A166FI86	A0A167WT60	Protein kinase domain-containing protein.	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	0.869
A0A166HDY0	A0A166FI86	Kinase-like protein.	Protein kinase domain-containing protein.	0.896
A0A166HDY0	A0A166P5Y2	Kinase-like protein.	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	0.588
A0A166HDY0	A0A166U8C4	Kinase-like protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.733
A0A166HDY0	A0A166W4W6	Kinase-like protein.	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	0.801
A0A166HDY0	A0A166XFB5	Kinase-like protein.	Kinase-like protein.	0.589
A0A166HDY0	A0A167WT30	Kinase-like protein.	Kinase-like protein.	0.803
A0A166HDY0	A0A167WT60	Kinase-like protein.	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	0.800
A0A166P5Y2	A0A166FI86	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.946
A0A166P5Y2	A0A166HDY0	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	Kinase-like protein.	0.588
A0A166P5Y2	A0A166U8C4	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.851

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.923

expected number of edges:

12

PPI enrichment p-value:

0.101

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051403

Stress-activated MAPK cascade

4 of 13

2.53

3.18

9.53e-07

GO:0006468

Protein phosphorylation

9 of 297

1.52

2.7

6.35e-10

GO:0051301

Cell division

5 of 132

1.62

1.89

2.46e-05

GO:0071310

Cellular response to organic substance

4 of 87

1.71

1.62

0.00026

GO:0071554

Cell wall organization or biogenesis

4 of 130

1.53

1.28

0.0011

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004709

MAP kinase kinase kinase activity

4 of 6

2.87

4.16

1.91e-08

GO:0004674

Protein serine/threonine kinase activity

9 of 249

1.6

3.1

6.11e-11

GO:0005524

ATP binding

9 of 948

1.02

1.16

1.04e-06

GO:1901363

Heterocyclic compound binding

10 of 2877

0.58

0.49

0.00035

GO:0097159

Organic cyclic compound binding

10 of 2896

0.58

0.48

0.00036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10482

MADS SRF-like, and Hippo signaling pathway - multiple species

6 of 17

2.59

5.49

1.88e-11

CL:10485

MADS SRF-like, and Smooth muscle protein/calponin

5 of 10

2.74

5.04

2.84e-10

CL:4336

Stress-activated MAPK cascade

4 of 11

2.6

3.57

1.79e-07

CL:4338

MAPK1 (ERK2) activation, and MAP kinase kinase kinase activity

2 of 6

2.57

1.35

0.0034

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

5 of 9

2.79

5.41

6.06e-11

map04111

Cell cycle - yeast

6 of 127

1.72

2.79

4.92e-08

map04113

Meiosis - yeast

5 of 148

1.57

1.99

6.23e-06

map04011

MAPK signaling pathway - yeast

5 of 221

1.4

1.58

3.26e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2871796

FCERI mediated MAPK activation

5 of 13

2.63

4.59

1.68e-09

MAP-2454202

Fc epsilon receptor (FCERI) signaling

5 of 34

2.21

3.53

5.60e-08

MAP-168256

Immune System

9 of 798

1.09

1.33

3.69e-07

MAP-168249

Innate Immune System

5 of 517

1.03

0.67

0.0126

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005816

Spindle pole body

5 of 28

2.29

3.65

4.71e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 371

1.43

2.45

3.42e-10

KW-0067

ATP-binding

6 of 531

1.1

1.04

0.00023

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001245

Serine-threonine/tyrosine-protein kinase, catalytic domain

7 of 13

2.77

7.23

1.14e-14

IPR046349

C1-like domain superfamily

5 of 17

2.51

4.37

3.17e-09

IPR002219

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

5 of 17

2.51

4.37

3.17e-09

IPR017441

Protein kinase, ATP binding site

9 of 187

1.73

3.7

5.71e-12

IPR000719

Protein kinase domain

9 of 256

1.59

3.06

5.98e-11

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00220

Serine/Threonine protein kinases, catalytic domain

9 of 159

1.8

4.22

3.03e-13

SM00033

Calponin homology domain

4 of 17

2.41

3.3

4.08e-07

SM00109

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

3 of 14

2.37

2.28

4.70e-05

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