A0A166NRX6 protein (Fibularhizoctonia sp. CBS109695)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

A0A166NRX6

Para-aminobenzoate synthase. (787 aa)

Predicted Functional Partners:

A0A166IBC2

0.999

A0A165Y0Z4

0.995

A0A167UT20

0.995

A0A166JTM5

0.988

A0A166DYL4

0.966

A0A166WEJ7

0.953

A0A166JHF9

0.937

A0A166S0E1

0.908

A0A166DG40

0.871

A0A166JPK1

0.864

Your Current Organism:

Fibularhizoctonia sp. CBS109695

NCBI taxonomy Id: 436010
Other names: F. sp. CBS 109695, Fibularhizoctonia sp. CBS 109695, Fibulorhizoctonia sp. CBS 109695

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A165Y0Z4	A0A166DG40	Anthranilate phosphoribosyltransferase.	Histidinol-phosphate aminotransferase.	0.845
A0A165Y0Z4	A0A166DYL4	Anthranilate phosphoribosyltransferase.	Chorismate synthase.	0.914
A0A165Y0Z4	A0A166IBC2	Anthranilate phosphoribosyltransferase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.999
A0A165Y0Z4	A0A166JHF9	Anthranilate phosphoribosyltransferase.	Anthranilate synthase component.	0.998
A0A165Y0Z4	A0A166JTM5	Anthranilate phosphoribosyltransferase.	Tryptophan synthase.	0.997
A0A165Y0Z4	A0A166NRX6	Anthranilate phosphoribosyltransferase.	Para-aminobenzoate synthase.	0.995
A0A165Y0Z4	A0A166WEJ7	Anthranilate phosphoribosyltransferase.	Chorismate mutase.	0.857
A0A166DG40	A0A165Y0Z4	Histidinol-phosphate aminotransferase.	Anthranilate phosphoribosyltransferase.	0.845
A0A166DG40	A0A166DYL4	Histidinol-phosphate aminotransferase.	Chorismate synthase.	0.908
A0A166DG40	A0A166IBC2	Histidinol-phosphate aminotransferase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.857
A0A166DG40	A0A166JHF9	Histidinol-phosphate aminotransferase.	Anthranilate synthase component.	0.900
A0A166DG40	A0A166JTM5	Histidinol-phosphate aminotransferase.	Tryptophan synthase.	0.979
A0A166DG40	A0A166NRX6	Histidinol-phosphate aminotransferase.	Para-aminobenzoate synthase.	0.871
A0A166DG40	A0A166WEJ7	Histidinol-phosphate aminotransferase.	Chorismate mutase.	0.915
A0A166DG40	A0A167UT20	Histidinol-phosphate aminotransferase.	Anthranilate phosphoribosyltransferase.	0.845
A0A166DYL4	A0A165Y0Z4	Chorismate synthase.	Anthranilate phosphoribosyltransferase.	0.914
A0A166DYL4	A0A166DG40	Chorismate synthase.	Histidinol-phosphate aminotransferase.	0.908
A0A166DYL4	A0A166IBC2	Chorismate synthase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.985
A0A166DYL4	A0A166JHF9	Chorismate synthase.	Anthranilate synthase component.	0.976
A0A166DYL4	A0A166JTM5	Chorismate synthase.	Tryptophan synthase.	0.979

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.855

expected number of edges:

13

PPI enrichment p-value:

2.76e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000272

Negative regulation of signaling receptor activity

3 of 4

3.06

2.55

2.32e-05

GO:0050730

Regulation of peptidyl-tyrosine phosphorylation

3 of 5

2.96

2.54

2.32e-05

GO:0007166

Cell surface receptor signaling pathway

5 of 147

1.72

1.98

2.64e-05

GO:0006469

Negative regulation of protein kinase activity

3 of 19

2.38

1.97

0.00020

GO:0048585

Negative regulation of response to stimulus

4 of 87

1.85

1.76

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016755

Aminoacyltransferase activity

3 of 7

2.82

2.42

3.67e-05

GO:0017124

SH3 domain binding

3 of 9

2.71

2.41

3.67e-05

GO:0001784

Phosphotyrosine residue binding

3 of 11

2.62

2.39

3.67e-05

GO:0005102

Signaling receptor binding

4 of 59

2.02

2.17

3.67e-05

GO:0019901

Protein kinase binding

3 of 76

1.78

1.25

0.0029

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

3 of 11

2.62

2.29

5.72e-05

GO:0071944

Cell periphery

5 of 929

0.92

0.49

0.0458

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:662

Mixed, incl. Regulation of cell migration, and Protein tyrosine kinase activity

6 of 61

2.18

4.03

2.71e-09

CL:685

Phosphotyrosine residue binding, and Transmembrane receptor protein kinase activity

3 of 20

2.36

2.07

0.00012

CL:768

VHS domain, and Semaphorin interactions

2 of 5

2.79

1.61

0.0012

CL:688

Mixed, incl. Phosphotyrosine residue binding, and Basal plasma membrane

2 of 13

2.37

1.22

0.0055

CL:1687

Mixed, incl. Protein tyrosine phosphatase, catalytic domain, and EGF-like domain

2 of 28

2.04

0.89

0.0212

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

4 of 223

1.44

1.2

0.0013

map04120

Ubiquitin mediated proteolysis

3 of 173

1.42

0.87

0.0114

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

3 of 8

2.76

2.47

2.94e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02761

CBL proto-oncogene N-terminus, EF hand-like domain

3 of 14

2.52

2.0

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024159

Adaptor protein Cbl, PTB domain

3 of 7

2.82

2.21

8.99e-05

IPR014741

Adaptor protein Cbl, EF hand-like

3 of 15

2.49

1.89

0.00030

IPR000980

SH2 domain

3 of 84

1.74

0.81

0.0257

IPR036860

SH2 domain superfamily

3 of 94

1.69

0.79

0.0268

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

3 of 93

1.69

0.96

0.0114

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