A0A166Q9A8 protein (Fibularhizoctonia sp. CBS109695)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

A0A166Q9A8

P-loop containing nucleoside triphosphate hydrolase protein. (1774 aa)

Predicted Functional Partners:

A0A166X028

0.952

A0A166TCJ3

0.944

A0A166F5R7

0.943

A0A166AZS9

0.938

A0A166BAY1

0.938

A0A166SCA6

0.938

A0A166R742

0.930

A0A166TZ92

0.929

A0A167VPH6

0.929

A0A166NSJ6

0.928

Your Current Organism:

Fibularhizoctonia sp. CBS109695

NCBI taxonomy Id: 436010
Other names: F. sp. CBS 109695, Fibularhizoctonia sp. CBS 109695, Fibulorhizoctonia sp. CBS 109695

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A166AZS9	A0A166BAY1	WD-repeat-containing protein.	Ribosomal protein S5 domain 2-like protein.	0.963
A0A166AZS9	A0A166F5R7	WD-repeat-containing protein.	Ribosomal protein S5 domain 2-like protein.	0.967
A0A166AZS9	A0A166NSJ6	WD-repeat-containing protein.	Uncharacterized protein.	0.966
A0A166AZS9	A0A166Q9A8	WD-repeat-containing protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.938
A0A166AZS9	A0A166R742	WD-repeat-containing protein.	RNase_PH domain-containing protein.	0.970
A0A166AZS9	A0A166SCA6	WD-repeat-containing protein.	Utp14-domain-containing protein.	0.994
A0A166AZS9	A0A166TCJ3	WD-repeat-containing protein.	Uncharacterized protein.	0.981
A0A166AZS9	A0A166TZ92	WD-repeat-containing protein.	TPR-like protein.	0.992
A0A166AZS9	A0A167VPH6	WD-repeat-containing protein.	Exosome complex exonuclease RRP40.	0.974
A0A166BAY1	A0A166AZS9	Ribosomal protein S5 domain 2-like protein.	WD-repeat-containing protein.	0.963
A0A166BAY1	A0A166F5R7	Ribosomal protein S5 domain 2-like protein.	Ribosomal protein S5 domain 2-like protein.	0.999
A0A166BAY1	A0A166NSJ6	Ribosomal protein S5 domain 2-like protein.	Uncharacterized protein.	0.993
A0A166BAY1	A0A166Q9A8	Ribosomal protein S5 domain 2-like protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.938
A0A166BAY1	A0A166R742	Ribosomal protein S5 domain 2-like protein.	RNase_PH domain-containing protein.	0.999
A0A166BAY1	A0A166SCA6	Ribosomal protein S5 domain 2-like protein.	Utp14-domain-containing protein.	0.977
A0A166BAY1	A0A166TCJ3	Ribosomal protein S5 domain 2-like protein.	Uncharacterized protein.	0.999
A0A166BAY1	A0A166TZ92	Ribosomal protein S5 domain 2-like protein.	TPR-like protein.	0.967
A0A166BAY1	A0A166X028	Ribosomal protein S5 domain 2-like protein.	TPR-like protein.	0.921
A0A166BAY1	A0A167VPH6	Ribosomal protein S5 domain 2-like protein.	Exosome complex exonuclease RRP40.	0.999
A0A166F5R7	A0A166AZS9	Ribosomal protein S5 domain 2-like protein.	WD-repeat-containing protein.	0.967

page 1 of 6

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0522

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099560

Synaptic membrane adhesion

5 of 12

2.84

4.76

1.30e-09

GO:0035335

Peptidyl-tyrosine dephosphorylation

4 of 27

2.39

2.73

5.75e-06

GO:0019221

Cytokine-mediated signaling pathway

6 of 181

1.74

2.39

1.81e-06

GO:0097374

Sensory neuron axon guidance

2 of 4

2.92

1.36

0.0035

GO:0070498

interleukin-1-mediated signaling pathway

2 of 7

2.68

1.21

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004908

interleukin-1 receptor activity

4 of 4

3.22

4.35

1.23e-08

GO:0061809

NAD+ nucleotidase, cyclic ADP-ribose generating

3 of 15

2.52

2.13

0.00011

GO:0050135

NAD(P)+ nucleosidase activity

3 of 15

2.52

2.13

0.00011

GO:0004725

Protein tyrosine phosphatase activity

4 of 97

1.84

1.86

0.00011

GO:0008201

Heparin binding

4 of 114

1.77

1.75

0.00016

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34025644

(2021) Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation.

3 of 39

2.11

1.48

0.0014

PMID:27231948

(2016) The Function of Fish Cytokines.

3 of 40

2.1

1.48

0.0014

PMID:35371107

(2022) Transcriptome Sequencing Reveals the Antiviral Innate Immunity by IFN-gamma in Chinese Sturgeon Macrophages.

2 of 12

2.44

1.16

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4439

NAD+ nucleosidase activity, and interleukin-1-mediated signaling pathway

6 of 17

2.77

6.02

3.38e-12

CL:4443

interleukin-1-mediated signaling pathway, and Inflammatory response

4 of 5

3.13

4.47

6.78e-09

CL:7095

Receptor-type tyrosine-protein phosphatases, and Synaptic membrane adhesion

4 of 21

2.5

3.38

3.39e-07

CL:7097

Synaptic membrane adhesion, and Presynaptic membrane assembly

3 of 13

2.59

2.46

2.65e-05

CL:7099

Synaptic membrane adhesion, and NTF3 activates NTRK3 signaling

2 of 5

2.82

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04520

Adherens junction

4 of 105

1.8

1.9

7.30e-05

map04910

Insulin signaling pathway

4 of 157

1.63

1.68

0.00012

map04620

Toll-like receptor signaling pathway

3 of 91

1.74

1.49

0.00067

map04514

Cell adhesion molecules

4 of 210

1.5

1.46

0.00027

map04010

MAPK signaling pathway

5 of 361

1.36

1.41

0.00012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-388844

Receptor-type tyrosine-protein phosphatases

5 of 24

2.54

4.43

2.60e-09

MAP-446652

Interleukin-1 family signaling

7 of 108

2.03

4.21

1.69e-10

MAP-8849932

Synaptic adhesion-like molecules

4 of 21

2.5

3.37

3.63e-07

MAP-6794362

Protein-protein interactions at synapses

5 of 89

1.97

2.89

4.72e-07

MAP-9020702

Interleukin-1 signaling

5 of 95

1.94

2.83

5.39e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 70

1.85

1.25

0.0032

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004074

Interleukin-1 receptor type I/II

4 of 7

2.98

3.72

1.52e-07

IPR015621

Interleukin-1 receptor family

4 of 10

2.82

3.59

2.31e-07

IPR000157

Toll/interleukin-1 receptor homology (TIR) domain

3 of 29

2.24

1.68

0.00065

IPR035897

Toll/interleukin-1 receptor homology (TIR) domain superfamily

3 of 31

2.21

1.65

0.00070

IPR003598

Immunoglobulin subtype 2

5 of 245

1.53

1.52

0.00021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00194

Protein tyrosine phosphatase, catalytic domain

3 of 39

2.11

1.59

0.00085

SM00409

Immunoglobulin

5 of 351

1.38

1.2

0.00085

SM00255

Toll - interleukin 1 - resistance

2 of 14

2.38

1.09

0.0098

SM00408

Immunoglobulin C-2 Type

3 of 206

1.39

0.67

0.0378

SM00060

Fibronectin type 3 domain

3 of 198

1.4

0.67

0.0378

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